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    Gfm1 G elongation factor, mitochondrial 1 [ Mus musculus (house mouse) ]

    Gene ID: 28030, updated on 12-May-2024

    Summary

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    Official Symbol
    Gfm1provided by MGI
    Official Full Name
    G elongation factor, mitochondrial 1provided by MGI
    Primary source
    MGI:MGI:107339
    See related
    Ensembl:ENSMUSG00000027774 AllianceGenome:MGI:107339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gfm; D3Wsu133e
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to act upstream of or within translational elongation. Located in mitochondrion. Is expressed in embryo and extraembryonic component. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 23.8), placenta adult (RPKM 13.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gfm1 in Genome Data Viewer
    Location:
    3 E1; 3 30.96 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67337448..67382401)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67430115..67475068)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene arginine/serine-rich coiled-coil 1 Neighboring gene predicted gene, 22295 Neighboring gene STARR-seq mESC enhancer starr_07884 Neighboring gene STARR-positive B cell enhancer ABC_E6060 Neighboring gene STARR-positive B cell enhancer mm9_chr3:67177807-67178108 Neighboring gene myeloid leukemia factor 1 Neighboring gene retinoic acid receptor responder (tazarotene induced) 1 Neighboring gene latexin Neighboring gene STARR-seq mESC enhancer starr_07890 Neighboring gene STARR-seq mESC enhancer starr_07891 Neighboring gene predicted gene, 40067 Neighboring gene predicted gene, 35299

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations. Molina-Berenguer M, et al. FASEB J, 2022 Jan. PMID 34919756
    2. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Almeida L, et al. Immunity, 2021 Jan 12. PMID 33238133, Free PMC Article
    3. Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and Gfm, and mapping of GFM to human chromosome 3q25.1-q26.2. Gao J, et al. Genomics, 2001 May 15. PMID 11374907
    4. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
    5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations.
      Title: Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor G, mitochondrial
    Names
    EF-Gmt
    G elongation factor 1
    elongation factor G 1, mitochondrial
    elongation factor G1
    mEF-G 1
    mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138591.2 → NP_613057.2  elongation factor G, mitochondrial

      See identical proteins and their annotated locations for NP_613057.2

      Status: VALIDATED

      Source sequence(s)
      AC124190
      Consensus CDS
      CCDS38449.1
      UniProtKB/Swiss-Prot
      Q8K0D5, Q921D6, Q924I0
      Related
      ENSMUSP00000076503.7, ENSMUST00000077271.9
      Conserved Domains (6) summary
      cd01886
      Location:49 → 321
      EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
      PRK12740
      Location:53 → 732
      PRK12740; elongation factor G; Reviewed
      cd01434
      Location:525 → 641
      EFG_mtEFG1_IV; EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2 ...
      cd04097
      Location:647 → 724
      mtEFG1_C; mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating ...
      cd04091
      Location:353 → 432
      mtEFG1_II_like; Domain II of mitochondrial elongation factor G1-like proteins found in eukaryotes
      cd16262
      Location:447 → 522
      EFG_III; Domain III of Elongation Factor G (EFG)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      67337448..67382401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0D5.1 GenPept UniProtKB/Swiss-Prot:Q8K0D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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