Ddx28 DEAD box helicase 28 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx28provided by MGI
Official Full Name: DEAD box helicase 28provided by MGI
Primary source: MGI:MGI:1919236
See related: Ensembl:ENSMUSG00000045538 AllianceGenome:MGI:1919236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mddx28; 2410004K13Rik
Summary: Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial large ribosomal subunit assembly. Predicted to act upstream of or within ribosome biogenesis. Located in mitochondrion. Orthologous to human DDX28 (DEAD-box helicase 28). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.08 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106736248..106738118, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106009616..106011486, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables rRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial large ribosomal subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial large ribosomal subunit assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX28

Names: ATP-dependent RNA helicase Ddx28; DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28; mitochondrial DEAD box protein 28

NP_082314.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028038.3 → NP_082314.2 probable ATP-dependent RNA helicase DDX28

See identical proteins and their annotated locations for NP_082314.2

Status: VALIDATED

Source sequence(s)

AC133499, AK163480, BC120582

Consensus CDS

CCDS22626.1

UniProtKB/Swiss-Prot

Q0VBM0, Q3TQM0, Q9CWT6

Related

ENSMUSP00000058950.6, ENSMUST00000058579.7

Conserved Domains (3) summary

PRK01297
Location:28 → 539

PRK01297; ATP-dependent RNA helicase RhlB; Provisional

pfam00271
Location:376 → 492

Helicase_C; Helicase conserved C-terminal domain

cl21455
Location:128 → 343

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases