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    Srpra signal recognition particle receptor alpha [ Mus musculus (house mouse) ]

    Gene ID: 67398, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Srpraprovided by MGI
    Official Full Name
    signal recognition particle receptor alphaprovided by MGI
    Primary source
    MGI:MGI:1914648
    See related
    Ensembl:ENSMUSG00000032042 AllianceGenome:MGI:1914648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Srpr; D11Mgi27; 1300011P19Rik
    Summary
    Predicted to enable GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in endoplasmic reticulum. Predicted to be part of signal recognition particle receptor complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cap mesenchyme; female associated reproductive structure; male associated reproductive structure; renal interstitium; and testis. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 54.6), placenta adult (RPKM 40.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srpra in Genome Data Viewer
    Location:
    9 A4; 9 20.06 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35122499..35128299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35211203..35217003)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RNA pseudouridylate synthase domain containing 4 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene ribosomal protein L36 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling. Farber CR, et al. Physiol Genomics, 2009 May 13. PMID 19336533, Free PMC Article
    2. The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains. Schlenker O, et al. J Biol Chem, 2006 Mar 31. PMID 16439358
    3. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle receptor subunit alpha
    Names
    DP-alpha
    SR-alpha
    docking protein alpha
    signal recognition particle receptor ('docking protein')

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026130.1 → NP_080406.1  signal recognition particle receptor subunit alpha

      See identical proteins and their annotated locations for NP_080406.1

      Status: PROVISIONAL

      Source sequence(s)
      AK004967
      Consensus CDS
      CCDS22959.1
      UniProtKB/Swiss-Prot
      Q8VC45, Q921H1, Q9DBG7
      Related
      ENSMUSP00000034541.6, ENSMUST00000034541.12
      Conserved Domains (4) summary
      smart00963
      Location:322 → 395
      SRP54_N; SRP54-type protein, helical bundle domain
      cd03115
      Location:417 → 613
      SRP; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The ...
      TIGR00064
      Location:334 → 633
      ftsY; signal recognition particle-docking protein FtsY
      pfam04086
      Location:27 → 296
      SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      35122499..35128299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBG7.1 GenPept UniProtKB/Swiss-Prot:Q9DBG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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