Magohb mago homolog B, exon junction complex core component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Magohbprovided by MGI
Official Full Name: mago homolog B, exon junction complex core componentprovided by MGI
Primary source: MGI:MGI:1913691
See related: Ensembl:ENSMUSG00000030188 AllianceGenome:MGI:1913691
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mago; Magoh; Magoh-rs1; 2010012C16Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to act upstream of or within mRNA processing and mRNA transport. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of exon-exon junction complex and spliceosomal complex. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 7.8), liver E14 (RPKM 7.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (131261351..131270207, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (131284389..131293244, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay
Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.
Reexpression of KMT2B was sufficient to reinstate an active MagohB promoter.
Title: The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U2-type catalytic step 1 spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
part_of exon-exon junction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction subcomplex mago-y14	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein mago nashi homolog 2

Names: mago nashi protein; mago-nashi homolog B; mago-nashi homolog, proliferation-associated, related sequence 1; protein mago nashi homolog 1-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001327860.1 → NP_001314789.1 protein mago nashi homolog 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, resulting in the use of a downstream in-frame translational start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK008200, BE649735

Consensus CDS

CCDS85172.1

UniProtKB/TrEMBL

G3UZW7

Related

ENSMUSP00000134663.2, ENSMUST00000173837.6

Conserved Domains (1) summary

cl03715
Location:1 → 102

Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
NM_025564.2 → NP_079840.2 protein mago nashi homolog 2 isoform 1

See identical proteins and their annotated locations for NP_079840.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK008200

Consensus CDS

CCDS39670.2

UniProtKB/TrEMBL

A0A023T778

Related

ENSMUSP00000032307.6, ENSMUST00000032307.12

Conserved Domains (1) summary

cd11295
Location:6 → 148

Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

131261351..131270207 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152262.1 → XP_036008155.1 protein mago nashi homolog 2 isoform X1

UniProtKB/TrEMBL

G3UZW7

Conserved Domains (1) summary

cl03715
Location:1 → 102

Mago_nashi; Mago nashi proteins, integral members of the exon junction complex