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    Wfdc3 WAP four-disulfide core domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 71856, updated on 9-May-2024

    Summary

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    Official Symbol
    Wfdc3provided by MGI
    Official Full Name
    WAP four-disulfide core domain 3provided by MGI
    Primary source
    MGI:MGI:1923897
    See related
    Ensembl:ENSMUSG00000076434 AllianceGenome:MGI:1923897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700015L13Rik; 1700127F16Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; epididymis; and lung. Orthologous to human WFDC3 (WAP four-disulfide core domain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 25.7) and genital fat pad adult (RPKM 2.2) See more
    Orthologs
    human all
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    Genomic context

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    See Wfdc3 in Genome Data Viewer
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164573222..164587914, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164731226..164745994, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor, Kunitz type 4 Neighboring gene serine protease inhibitor, Kunitz type 5 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_06333 Neighboring gene STARR-positive B cell enhancer ABC_E417 Neighboring gene ubiquitin-conjugating enzyme E2C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2. Sivashanmugam P, et al. Gene, 2003 Jul 17. PMID 12909348
    2. Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Bademci G, et al. Proc Natl Acad Sci U S A, 2022 Jun 28. PMID 35727972, Free PMC Article
    3. Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†. Andrade AD, et al. Biol Reprod, 2021 Jan 4. PMID 33034631
    4. The evolution of a genetic locus encoding small serine proteinase inhibitors. Clauss A, et al. Biochem Biophys Res Commun, 2005 Jul 29. PMID 15950183, Free PMC Article
    5. Forkhead box a2 (FOXA2) is essential for uterine function and fertility. Kelleher AM, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28049832, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WAP four-disulfide core domain protein 3
    Names
    putative protease inhibitor WAP14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418734.1 → NP_001405663.1  WAP four-disulfide core domain protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591127
      UniProtKB/Swiss-Prot
      Q14AE4

    2. NM_001418735.1 → NP_001405664.1  WAP four-disulfide core domain protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591127
      UniProtKB/Swiss-Prot
      Q14AE4

    3. NM_027961.2 → NP_082237.1  WAP four-disulfide core domain protein 3 precursor

      See identical proteins and their annotated locations for NP_082237.1

      Status: VALIDATED

      Source sequence(s)
      AL591127
      Consensus CDS
      CCDS17053.1
      UniProtKB/Swiss-Prot
      Q14AE4
      Related
      ENSMUSP00000099385.4, ENSMUST00000103096.10
      Conserved Domains (1) summary
      pfam00095
      Location:23 → 58
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RNA

    1. NR_184809.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591127
      Related
      ENSMUST00000109328.8

    2. NR_184810.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591127
      Related
      ENSMUST00000130227.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164573222..164587914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500193.3 → XP_006500256.1  WAP four-disulfide core domain protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500256.1

      UniProtKB/Swiss-Prot
      Q14AE4
      Conserved Domains (1) summary
      pfam00095
      Location:23 → 58
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    2. XM_036162576.1 → XP_036018469.1  WAP four-disulfide core domain protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q14AE4
      Conserved Domains (1) summary
      pfam00095
      Location:23 → 58
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    3. XM_030252094.1 → XP_030107954.1  WAP four-disulfide core domain protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q14AE4
      Conserved Domains (1) summary
      pfam00095
      Location:23 → 58
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14AE4.1 GenPept UniProtKB/Swiss-Prot:Q14AE4

    Gene LinkOut

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