Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uggt1provided by RGD
Official Full Name: UDP-glucose glycoprotein glucosyltransferase 1provided by RGD
Primary source: RGD:619710
See related: Ensembl:ENSRNOG00000014901 AllianceGenome:RGD:619710
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UGT1; Uggt; rUGT1; Ugcgl1
Summary: Enables UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Predicted to be involved in ER-associated misfolded protein catabolic process and protein N-linked glycosylation via asparagine. Located in endoplasmic reticulum lumen and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 223.8), Thymus (RPKM 198.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q21

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (45851127..45964454, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (38355229..38468473, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (42692156..42805680, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UGGT recognizes the hydrophobic region of client glycoproteins.
Title: The recognition motif of the glycoprotein-folding sensor enzyme UDP-Glc:glycoprotein glucosyltransferase.
how UGGT recognizes incompletely folded glycoproteins
Title: Glycopeptide specificity of the secretory protein folding sensor UDP-glucose glycoprotein:glucosyltransferase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124983 (e-PCR)
- UniSTS:161805

UGCGL1 (e-PCR)
- UniSTS:513861

D9Rat147 (e-PCR), detects polymorphism
- UniSTS:228334

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose:glycoprotein glucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucose:glycoprotein glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucose:glycoprotein glucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables UDP-glucose:glycoprotein glucosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' post-translational protein folding	TAS Traceable Author Statement more info	PubMed
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-glucosylation	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	TAS Traceable Author Statement more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UDP-glucose:glycoprotein glucosyltransferase 1

Names: RUGT; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein: glucosyltransferase UGGT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133596.2 → NP_598280.1 UDP-glucose:glycoprotein glucosyltransferase 1 precursor

See identical proteins and their annotated locations for NP_598280.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9JLA3

UniProtKB/TrEMBL

A6INC3

Related

ENSRNOP00000020558.3, ENSRNOT00000020558.6

Conserved Domains (2) summary

cd06432
Location:1232 → 1479

GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family

pfam06427
Location:21 → 1178

UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

45851127..45964454 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244735.5 → XP_006244797.1 UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q9JLA3

UniProtKB/TrEMBL

A0A8I5ZR75, A6INC3

Related

ENSRNOP00000080848.1

Conserved Domains (2) summary

cd06432
Location:1248 → 1495

GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family

pfam06427
Location:45 → 1194

UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase