Adam2 ADAM metallopeptidase domain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam2provided by RGD
Official Full Name: ADAM metallopeptidase domain 2provided by RGD
Primary source: RGD:69299
See related: Ensembl:ENSRNOG00000017027 AllianceGenome:RGD:69299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ftnb; PH-30
Summary: Predicted to enable metalloendopeptidase activity. Involved in male gonad development and spermatogenesis. Located in acrosomal vesicle. Orthologous to human ADAM2 (ADAM metallopeptidase domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 339.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (44418191..44459570, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (40242651..40284025, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (42708536..42751281, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM2 silencing alleviates isoflurane-induced cognitive dysfunction by activating the PI3K/Akt signal pathway.
Title: Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats.

Submit: New GeneRIF Correction

General gene information

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Markers

Adam2 (e-PCR), detects polymorphism
- UniSTS:141027

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 2

Names: A disintegrin and metalloprotease domain 2 (Fertilin beta); ADAM 2; PH30; PH30-beta; a disintegrin and metallopeptidase domain 2; a disintegrin and metalloprotease domain (ADAM) 2; fertilin beta; fertilin subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020077.3 → NP_064462.2 disintegrin and metalloproteinase domain-containing protein 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6K6L5, F1M6W4

Related

ENSRNOP00000061122.4, ENSRNOT00000066478.4

Conserved Domains (4) summary

smart00050
Location:398 → 475

DISIN; Homologues of snake disintegrins

smart00608
Location:477 → 613

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:184 → 381

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:32 → 147

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

44418191..44459570 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093614.2 → XP_038949542.1 disintegrin and metalloproteinase domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

F1M6W4

Conserved Domains (4) summary

smart00050
Location:346 → 423

DISIN; Homologues of snake disintegrins

smart00608
Location:425 → 561

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:132 → 329

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:32 → 107

Pep_M12B_propep; Reprolysin family propeptide
XM_039093615.2 → XP_038949543.1 disintegrin and metalloproteinase domain-containing protein 2 isoform X2

Conserved Domains (3) summary

smart00050
Location:235 → 312

DISIN; Homologues of snake disintegrins

smart00608
Location:314 → 450

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:21 → 218

Reprolysin; Reprolysin (M12B) family zinc metalloprotease
XM_063274593.1 → XP_063130663.1 disintegrin and metalloproteinase domain-containing protein 2 isoform X2
XM_039093616.2 → XP_038949544.1 disintegrin and metalloproteinase domain-containing protein 2 isoform X3

Conserved Domains (3) summary

smart00050
Location:161 → 238

DISIN; Homologues of snake disintegrins

smart00608
Location:240 → 376

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:1 → 144

Reprolysin; Reprolysin (M12B) family zinc metalloprotease
XM_039093617.2 → XP_038949545.1 disintegrin and metalloproteinase domain-containing protein 2 isoform X4

Conserved Domains (3) summary

smart00050
Location:74 → 151

DISIN; Homologues of snake disintegrins

smart00608
Location:153 → 289

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:1 → 57

Reprolysin; Reprolysin (M12B) family zinc metalloprotease