Spon1 spondin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spon1provided by RGD
Official Full Name: spondin 1provided by RGD
Primary source: RGD:619918
See related: Ensembl:ENSRNOG00000058003 AllianceGenome:RGD:619918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sponf
Summary: Predicted to enable LBD domain binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within positive regulation of protein binding activity; positive regulation of protein processing; and regulation of amyloid precursor protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 310.7), Kidney (RPKM 268.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (177363526..177662689)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (167929049..168228239)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (178568777..178935715)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings justify further investigation of this novel positional candidate gene in BP control in hypertensive rat models and humans.
Title: Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene.
F-spondin may be an endogenous regulator of APP cleavage.
Title: Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.

Submit: New GeneRIF Correction

General gene information

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Markers

Spon1 (e-PCR), detects polymorphism
- UniSTS:526944

RH137699 (e-PCR)
- UniSTS:219786

D1Rat431 (e-PCR), detects polymorphism
- UniSTS:227214

d1rat279 (e-PCR)
- UniSTS:121492

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables LBD domain binding	IEA Inferred from Electronic Annotation more info
enables LBD domain binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spondin-1

Names: f-spondin; spondin 1, (f-spondin) extracellular matrix protein; spondin 1, extracellular matrix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172067.2 → NP_742064.2 spondin-1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P35446

UniProtKB/TrEMBL

A0A0G2K775, F1LND6, Q3B7D6

Related

ENSRNOP00000074092.1, ENSRNOT00000092099.2

Conserved Domains (4) summary

cd08544
Location:43 → 182

Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam00090
Location:562 → 610

TSP_1; Thrombospondin type 1 domain

pfam06468
Location:205 → 392

Spond_N; Spondin_N

pfam19028
Location:669 → 720

TSP1_spondin; Spondin-like TSP1 domain