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    Dlgap4 DLG associated protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286930, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Dlgap4provided by RGD
    Official Full Name
    DLG associated protein 4provided by RGD
    Primary source
    RGD:708350
    See related
    Ensembl:ENSRNOG00000020225 AllianceGenome:RGD:708350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dap4; DAP-4; SAPAP4
    Summary
    Enables protein domain specific binding activity. Predicted to be involved in regulation of postsynaptic neurotransmitter receptor activity. Located in dendrite; neuronal cell body; and plasma membrane. Orthologous to human DLGAP4 (DLG associated protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 89.3), Lung (RPKM 58.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dlgap4 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165584271..165731868)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145124189..145271791)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152752091..152846118)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101766 Neighboring gene uncharacterized LOC134486192 Neighboring gene uncharacterized LOC103691945 Neighboring gene uncharacterized LOC102551821 Neighboring gene myosin light chain 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA. Kindler S, et al. Brain Res Mol Brain Res, 2004 Jul 5. PMID 15207911
    2. Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. Welch JM, et al. J Comp Neurol, 2004 Apr 19. PMID 15024750
    3. nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP). Kawabe H, et al. J Biol Chem, 1999 Oct 22. PMID 10521485
    4. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. Takeuchi M, et al. J Biol Chem, 1997 May 2. PMID 9115257
    5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cholinergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic specialization IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic specialization ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disks large-associated protein 4
    Names
    PSD-95/SAP90-associated protein-4
    PSD-95/SAP90-binding protein 4
    SAP90/PSD-95-associated protein 4
    SAPAP-4
    discs, large homolog-associated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429777.1 → NP_001416706.1  disks large-associated protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P97839
      UniProtKB/TrEMBL
      A0A8I6ACV4

    2. NM_001429778.1 → NP_001416707.1  disks large-associated protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001429779.1 → NP_001416708.1  disks large-associated protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_001429780.1 → NP_001416709.1  disks large-associated protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001429781.1 → NP_001416710.1  disks large-associated protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    6. NM_173145.3 → NP_775168.2  disks large-associated protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P97839
      UniProtKB/TrEMBL
      A6KIB5, G3V927
      Related
      ENSRNOP00000034166.2, ENSRNOT00000037177.3
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      165584271..165731868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283180.1 → XP_063139250.1  disks large-associated protein 4 isoform X3

    2. XM_063283179.1 → XP_063139249.1  disks large-associated protein 4 isoform X2

    3. XM_039104402.2 → XP_038960330.1  disks large-associated protein 4 isoform X1

      Related
      ENSRNOP00000090954.1
      Conserved Domains (1) summary
      pfam03359
      Location:647 → 989
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. XM_039104406.2 → XP_038960334.1  disks large-associated protein 4 isoform X7

      Conserved Domains (1) summary
      pfam03359
      Location:17 → 298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. XM_039104408.2 → XP_038960336.1  disks large-associated protein 4 isoform X8

      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    6. XM_063283181.1 → XP_063139251.1  disks large-associated protein 4 isoform X6

    7. XM_039104405.2 → XP_038960333.1  disks large-associated protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A541
      Related
      ENSRNOP00000086332.1
      Conserved Domains (1) summary
      pfam03359
      Location:121 → 453
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    8. XM_039104404.2 → XP_038960332.1  disks large-associated protein 4 isoform X4

      Conserved Domains (1) summary
      pfam03359
      Location:130 → 462
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    9. XM_039104407.1 → XP_038960335.1  disks large-associated protein 4 isoform X7

      Conserved Domains (1) summary
      pfam03359
      Location:17 → 298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    10. XM_039104410.2 → XP_038960338.1  disks large-associated protein 4 isoform X8

      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97839.1 GenPept UniProtKB/Swiss-Prot:P97839

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