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    Trim35 tripartite motif-containing 35 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498538, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trim35provided by RGD
    Official Full Name
    tripartite motif-containing 35provided by RGD
    Primary source
    RGD:1564642
    See related
    Ensembl:ENSRNOG00000009449 AllianceGenome:RGD:1564642
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of mitotic cell cycle; and protein ubiquitination. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human TRIM35 (tripartite motif containing 35). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 853.9), Adrenal (RPKM 554.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44669222..44685766)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40493697..40510246)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42960255..42976798)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097020 Neighboring gene protein tyrosine kinase 2 beta Neighboring gene microRNA 6320 Neighboring gene stathmin 4 Neighboring gene adrenoceptor alpha 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. Lalonde JP, et al. J Biol Chem, 2004 Feb 27. PMID 14662771
    2. Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function. Kimura F, et al. J Biol Chem, 2003 Jul 4. PMID 12692137
    3. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in suppression of viral release by host IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM35
    Names
    tripartite motif protein 35
    tripartite motif-containing protein 35
    NP_001020313.2
    XP_017455266.1
    XP_063130624.1
    XP_063130625.1
    XP_063130626.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025142.2 → NP_001020313.2  E3 ubiquitin-protein ligase TRIM35

      See identical proteins and their annotated locations for NP_001020313.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085942, CB743135
      UniProtKB/Swiss-Prot
      Q4VBW2, Q5RKG6
      UniProtKB/TrEMBL
      A6K6M5, G3V769
      Related
      ENSRNOP00000012528.4, ENSRNOT00000012528.5
      Conserved Domains (4) summary
      cd00021
      Location:113 → 151
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:35 → 76
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13863
      Location:198 → 261
      DUF4200; Domain of unknown function (DUF4200)
      cl02614
      Location:317 → 503
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      44669222..44685766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599777.3 → XP_017455266.1  E3 ubiquitin-protein ligase TRIM35 isoform X3

    2. XM_063274555.1 → XP_063130625.1  E3 ubiquitin-protein ligase TRIM35 isoform X2

    3. XM_063274554.1 → XP_063130624.1  E3 ubiquitin-protein ligase TRIM35 isoform X1

    4. XM_063274556.1 → XP_063130626.1  E3 ubiquitin-protein ligase TRIM35 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKG6.1 GenPept UniProtKB/Swiss-Prot:Q5RKG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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