Pgs1 phosphatidylglycerophosphate synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pgs1provided by RGD
Official Full Name: phosphatidylglycerophosphate synthase 1provided by RGD
Primary source: RGD:1305052
See related: Ensembl:ENSRNOG00000002949 AllianceGenome:RGD:1305052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305052
Summary: Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrion. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 110.2), Lung (RPKM 103.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (103713306..103748924)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103214635..103250254)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (106994595..107030208)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In cancer cachexia, TNFalpha induces a higher energy wasting in liver mitochondria by increasing cardiolipin content via upregulation of phosphatidylglycerophosphate synthase expression.
Title: Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

NP_001414415.1

EC 2.7.8.5

XP_006247917.1

EC 2.7.8.5

XP_038943442.1

EC 2.7.8.5

XP_063125311.1

EC 2.7.8.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427486.1 → NP_001414415.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6ACK5, A6HL41, D4A5W8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

103713306..103748924

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247855.5 → XP_006247917.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006247917.1

UniProtKB/TrEMBL

A0A8I6ACK5, A6HL41, D4A5W8

Conserved Domains (2) summary

cd09135
Location:93 → 266

PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases

cd09137
Location:346 → 505

PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases
XM_063269241.1 → XP_063125311.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X2
XM_039087514.2 → XP_038943442.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X3

Conserved Domains (2) summary

cd09137
Location:168 → 327

PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases

cl15239
Location:1 → 88

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins