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    Usp21 ubiquitin specific peptidase 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688466, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Usp21provided by RGD
    Official Full Name
    ubiquitin specific peptidase 21provided by RGD
    Primary source
    RGD:1588822
    See related
    Ensembl:ENSRNOG00000038347 AllianceGenome:RGD:1588822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NEDD8-specific protease activity; thiol-dependent deubiquitinase; and transcription coactivator activity. Involved in neuron projection development. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 84.5), Spleen (RPKM 59.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86235122..86241663, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83702672..83709215, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89655016..89661150, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene G protein subunit gamma 5, pseudogene 1 Neighboring gene death effector domain-containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. Gong L, et al. J Biol Chem, 2000 May 12. PMID 10799498
    2. Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation. Nakagawa T, et al. Genes Dev, 2008 Jan 1. PMID 18172164, Free PMC Article
    3. BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. Khan A, et al. Proc Natl Acad Sci U S A, 2015 Jul 7. PMID 26100909, Free PMC Article
    4. Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Urbé S, et al. Mol Biol Cell, 2012 Mar. PMID 22298430, Free PMC Article
    5. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Belle JI, et al. Int J Biochem Cell Biol, 2014 May. PMID 24647359

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies indicate a key role for USP21 in the governance of microtubule- and centrosome-associated physiological processes.
      Title: Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187584

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deNEDDylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deNEDDylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deNEDDylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21
    Names
    deubiquitinating enzyme 21
    ubiquitin thioesterase 21
    ubiquitin thiolesterase 21
    ubiquitin-specific protease 21
    ubiquitin-specific-processing protease 21
    NP_001121110.1
    XP_063128688.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127638.2 → NP_001121110.1  ubiquitin carboxyl-terminal hydrolase 21

      See identical proteins and their annotated locations for NP_001121110.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      B2GUX4
      UniProtKB/TrEMBL
      A0A8I6A1T1
      Related
      ENSRNOP00000055192.4, ENSRNOT00000058390.4
      Conserved Domains (2) summary
      cd02674
      Location:213 → 556
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:212 → 555
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86235122..86241663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272618.1 → XP_063128688.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    RNA

    1. XR_010056937.1 RNA Sequence

    2. XR_010056938.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GUX4.1 GenPept UniProtKB/Swiss-Prot:B2GUX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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