Kif18b kinesin family member 18B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif18bprovided by RGD
Official Full Name: kinesin family member 18Bprovided by RGD
Primary source: RGD:1310360
See related: Ensembl:ENSRNOG00000021713 AllianceGenome:RGD:1310360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310360
Summary: Predicted to enable ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in several processes, including microtubule depolymerization; mitotic sister chromatid segregation; and regulation of cell division. Predicted to be located in cytosol; microtubule; and nuclear body. Predicted to be part of kinesin complex. Predicted to be active in mitotic spindle astral microtubule; mitotic spindle midzone; and nucleus. Orthologous to human KIF18B (kinesin family member 18B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 66.9), Spleen (RPKM 53.6) and 7 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q32.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (88370520..88392388, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87870424..87889895, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (91008294..91027760, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in astral microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle astral microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: kinesin-like protein KIF18B

Names: kinesin-like protein KIF18B-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039019.1 → NP_001034108.1 kinesin-like protein KIF18B

See identical proteins and their annotated locations for NP_001034108.1

Status: PROVISIONAL

Source sequence(s)

BC099126

UniProtKB/Swiss-Prot

Q4KLL9

UniProtKB/TrEMBL

A0A8L2R323

Related

ENSRNOP00000034491.3, ENSRNOT00000032339.5

Conserved Domains (2) summary

smart00129
Location:18 → 360

KISc; Kinesin motor, catalytic domain. ATPase

cd01370
Location:18 → 353

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

88370520..88392388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247505.5 → XP_006247567.1 kinesin-like protein KIF18B isoform X2

See identical proteins and their annotated locations for XP_006247567.1

UniProtKB/Swiss-Prot

Q4KLL9

UniProtKB/TrEMBL

A0A8L2R323

Related

ENSRNOP00000070718.2

Conserved Domains (2) summary

smart00129
Location:18 → 360

KISc; Kinesin motor, catalytic domain. ATPase

cd01370
Location:18 → 353

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
XM_008768283.4 → XP_008766505.1 kinesin-like protein KIF18B isoform X1

UniProtKB/TrEMBL

A0A8L2R323

Conserved Domains (2) summary

smart00129
Location:18 → 360

KISc; Kinesin motor, catalytic domain. ATPase

cd01370
Location:18 → 353

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup