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    Tmem119 transmembrane protein 119 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304581, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem119provided by RGD
    Official Full Name
    transmembrane protein 119provided by RGD
    Primary source
    RGD:1307573
    See related
    Ensembl:ENSRNOG00000000700 AllianceGenome:RGD:1307573
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307573
    Summary
    Predicted to be involved in several processes, including endochondral ossification; negative regulation of bone resorption; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within osteoblast differentiation. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human TMEM119 (transmembrane protein 119). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 223.1), Lung (RPKM 93.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem119 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48489157..48496214)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42828621..42835678)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48598498..48605704)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene selectin P ligand Neighboring gene uncharacterized LOC108352466 Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene spliceosome associated factor 3, U4/U6 recycling protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice. Mizuhashi K, et al. PLoS One, 2015. PMID 26207632, Free PMC Article
    2. OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis. Mizuhashi K, et al. Dev Growth Differ, 2012 May. PMID 22416756
    3. Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells. Tanaka K, et al. Bone, 2012 Jul. PMID 22579779
    4. Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. Hisa I, et al. J Biol Chem, 2011 Mar 18. PMID 21239498, Free PMC Article
    5. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. Kanamoto T, et al. BMC Dev Biol, 2009 Dec 21. PMID 20025746, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endochondral ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoblast proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 119
    Names
    transmembrane protein 119 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107155.1 → NP_001100625.1  transmembrane protein 119 precursor

      See identical proteins and their annotated locations for NP_001100625.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A0A8I6AD54, A6J222, B2RYL3, F6T7Z2
      Conserved Domains (1) summary
      pfam15724
      Location:21 → 277
      TMEM119; TMEM119 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48489157..48496214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598354.3 → XP_017453843.1  transmembrane protein 119 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD54, A6J222, B2RYL3, F6T7Z2
      Related
      ENSRNOP00000090180.1
      Conserved Domains (1) summary
      pfam15724
      Location:21 → 277
      TMEM119; TMEM119 family
    Nucleotide Protein Strain
    Heading Accession and Version

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