Myo6 myosin VI [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo6provided by RGD
Official Full Name: myosin VIprovided by RGD
Primary source: RGD:1560646
See related: Ensembl:ENSRNOG00000011852 AllianceGenome:RGD:1560646
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560646
Summary: Predicted to enable several functions, including ADP binding activity; actin filament binding activity; and calmodulin binding activity. Involved in response to xenobiotic stimulus. Located in several cellular components, including endocytic vesicle; microvillus; and ruffle membrane. Part of protein-containing complex. Used to study hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 464.2), Lung (RPKM 161.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (89967351..90122219)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (81087157..81242022)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (87583649..87731271)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a plaque accretion defect as the primary manifestation of myosin VI loss in Cx43 homeostasis, is reported.
Title: Myosin VI facilitates connexin 43 gap junction accretion.
data indicate that MVI plays an important role in myogenic cells, also during their differentiation into myotubes
Title: Involvement of unconventional myosin VI in myoblast function and myotube formation.
Myosin VI is localized in the sarcoplasmic reticulum, neuromuscular junction and muscle nuclei of skeletal muscle.
Title: Myosin VI in skeletal muscle: its localization in the sarcoplasmic reticulum, neuromuscular junction and muscle nuclei.
MVI and Dock7 may help explain a mechanism for MVI-dependent regulation of actin cytoskeleton organization.
Title: Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells.
Decrease of MVI expression caused severe changes in cell size and morphology, and profound defects in actin cytoskeleton organization and Golgi structure. Also, significant inhibition of cell migration as well as cell proliferation was observed.
Title: Myosin VI in PC12 cells plays important roles in cell migration and proliferation but not in catecholamine secretion.
Results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity.
Title: BDNF-mediated neurotransmission relies upon a myosin VI motor complex.
alpha-AP-2 has a role in directing myosin VI-dependent endocytosis of CFTR; myosin VI is involved in membrane invagination and coated pit formation in enterocytes
Title: Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.
MVI also localized to secretory granules within rat pheochromocytoma PC12 cells as well as to the Golgi apparatus, endoplasmic reticulum and clathrin-coated pits.
Title: Myosin VI is associated with secretory granules and is present in the nucleus in adrenal medulla chromaffin cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048109 (e-PCR)
- UniSTS:109863

U49739 (e-PCR)
- UniSTS:125761

Myo6 (e-PCR), detects polymorphism
- UniSTS:143970

PMC124268P1 (e-PCR)
- UniSTS:270458

BF399451 (e-PCR)
- UniSTS:247686

RH133282 (e-PCR)
- UniSTS:216565

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to electrical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in inner ear auditory receptor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
NOT located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
is_active_in cochlear hair cell ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic endocytic zone	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-VI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427259.1 → NP_001414188.1 unconventional myosin-VI

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5Y7N7, A0A8I5ZWC2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

89967351..90122219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766423.3 → XP_008764645.1 unconventional myosin-VI isoform X1

See identical proteins and their annotated locations for XP_008764645.1

UniProtKB/TrEMBL

A0A8I5ZYN7, A0A8I6ACM8, A0A8I6AEW8

Related

ENSRNOP00000091730.1

Conserved Domains (3) summary

smart00242
Location:52 → 771

MYSc; Myosin. Large ATPases

cd01382
Location:71 → 759

MYSc_Myo6; class VI myosin, motor domain

pfam16521
Location:1177 → 1267

Myosin-VI_CBD; Myosin VI cargo binding domain
XM_039082536.2 → XP_038938464.1 unconventional myosin-VI isoform X2

UniProtKB/TrEMBL

A0A8I5ZYN7, A0A8I6AEW8, D4A5I9

Related

ENSRNOP00000016428.7
XM_008766425.4 → XP_008764647.1 unconventional myosin-VI isoform X3

See identical proteins and their annotated locations for XP_008764647.1

UniProtKB/TrEMBL

A0A8I6AEW8

Conserved Domains (3) summary

smart00242
Location:52 → 771

MYSc; Myosin. Large ATPases

cd01382
Location:71 → 759

MYSc_Myo6; class VI myosin, motor domain

pfam16521
Location:1145 → 1235

Myosin-VI_CBD; Myosin VI cargo binding domain
XM_063265552.1 → XP_063121622.1 unconventional myosin-VI isoform X4

UniProtKB/TrEMBL

A6I1N5
XM_063265553.1 → XP_063121623.1 unconventional myosin-VI isoform X5