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    Veph1 ventricular zone expressed PH domain-containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361954, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Veph1provided by RGD
    Official Full Name
    ventricular zone expressed PH domain-containing 1provided by RGD
    Primary source
    RGD:1308217
    See related
    Ensembl:ENSRNOG00000012427 AllianceGenome:RGD:1308217
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308217
    Summary
    Predicted to enable phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human VEPH1 (ventricular zone expressed PH domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 153.3), Kidney (RPKM 105.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Veph1 in Genome Data Viewer
    Location:
    2q31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (152592648..152847566, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (150291379..150537491, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (157869383..158156266, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485923 Neighboring gene cyclin L1 Neighboring gene H3.3 histone A, pseudogene 8 Neighboring gene high mobility group protein B1-like Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 44 Neighboring gene uncharacterized LOC120100839 Neighboring gene pentraxin 3 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling. Shathasivam P, et al. Proc Natl Acad Sci U S A, 2015 Jun 9. PMID 26039994, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-5-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of SMAD protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ventricular zone-expressed PH domain-containing protein homolog 1
    Names
    protein melted homolog
    ventricular zone expressed PH domain homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014171.1 → NP_001014193.1  ventricular zone-expressed PH domain-containing protein homolog 1

      See identical proteins and their annotated locations for NP_001014193.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087055
      UniProtKB/Swiss-Prot
      Q5PQS3
      UniProtKB/TrEMBL
      A6J5K5
      Related
      ENSRNOP00000016621.5, ENSRNOT00000016621.7
      Conserved Domains (2) summary
      cd01264
      Location:716 → 823
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain
      pfam00169
      Location:717 → 818
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      152592648..152847566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761051.4 → XP_008759273.1  ventricular zone-expressed PH domain-containing protein homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_008759273.1

      UniProtKB/TrEMBL
      A0A0G2K6S2, A6J5K5
      Conserved Domains (1) summary
      cd01264
      Location:716 → 824
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    2. XM_039102624.2 → XP_038958552.1  ventricular zone-expressed PH domain-containing protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6S2, A6J5K5
      Conserved Domains (1) summary
      cd01264
      Location:716 → 824
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    3. XM_039102623.2 → XP_038958551.1  ventricular zone-expressed PH domain-containing protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6S2, A6J5K5
      Conserved Domains (1) summary
      cd01264
      Location:716 → 824
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    4. XM_039102622.2 → XP_038958550.1  ventricular zone-expressed PH domain-containing protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6S2, A6J5K5
      Related
      ENSRNOP00000073921.1
      Conserved Domains (1) summary
      cd01264
      Location:716 → 824
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    5. XM_039102626.2 → XP_038958554.1  ventricular zone-expressed PH domain-containing protein homolog 1 isoform X2

      Conserved Domains (1) summary
      cd01264
      Location:537 → 645
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    6. XM_039102627.2 → XP_038958555.1  ventricular zone-expressed PH domain-containing protein homolog 1 isoform X3

      Conserved Domains (1) summary
      cd01264
      Location:322 → 430
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    7. XM_039102628.2 → XP_038958556.1  ventricular zone-expressed PH domain-containing protein homolog 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQS3.1 GenPept UniProtKB/Swiss-Prot:Q5PQS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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