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    Itpk1 inositol-tetrakisphosphate 1-kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500709, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Itpk1provided by RGD
    Official Full Name
    inositol-tetrakisphosphate 1-kinaseprovided by RGD
    Primary source
    RGD:1595691
    See related
    Ensembl:ENSRNOG00000008051 AllianceGenome:RGD:1595691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphotransferase activity, alcohol group as acceptor. Predicted to be involved in inositol phosphorylation and necroptotic process. Predicted to act upstream of or within neural tube development. Predicted to be located in apical plasma membrane. Orthologous to human ITPK1 (inositol-tetrakisphosphate 1-kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 48.7), Thymus (RPKM 39.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127475589..127609320, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121710750..121844501, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126448920..126582188, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692694 Neighboring gene chromogranin A Neighboring gene uncharacterized LOC102548189 Neighboring gene uncharacterized LOC102548370 Neighboring gene modulator of apoptosis 1 Neighboring gene GON7 subunit of KEOPS complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Wilson MP, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19482943, Free PMC Article
    2. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase. Yang X, et al. Biochem J, 2000 Nov 1. PMID 11042108, Free PMC Article
    3. Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. Wilson MP, et al. J Biol Chem, 1996 May 17. PMID 8662638
    4. Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. Yang L, et al. J Cell Sci, 2006 Apr 1. PMID 16537650
    5. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Dovey CM, et al. Mol Cell, 2018 Jun 7. PMID 29883610, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol tetrakisphosphate 1-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol tetrakisphosphate 1-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol tetrakisphosphate 6-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4-trisphosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,3,4-trisphosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4-trisphosphate 6-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,3,4-trisphosphate 6-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol trisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol-tetrakisphosphate 1-kinase
    Names
    inositol 1,3,4-triphosphate 5/6 kinase
    NP_001178914.1
    XP_008763064.1
    XP_017449793.1
    XP_038968683.1
    XP_063118403.1
    XP_063118404.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191985.1 → NP_001178914.1  inositol-tetrakisphosphate 1-kinase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AUY6, D3ZQM7
      Related
      ENSRNOP00000010656.7, ENSRNOT00000010656.8
      Conserved Domains (1) summary
      cl17255
      Location:1 → 318
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      127475589..127609320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112755.2 → XP_038968683.1  inositol-tetrakisphosphate 1-kinase isoform X4

      Conserved Domains (1) summary
      cl17255
      Location:1 → 241
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    2. XM_017594304.3 → XP_017449793.1  inositol-tetrakisphosphate 1-kinase isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7L4, A0A8I6AUY6
      Related
      ENSRNOP00000074255.1

    3. XM_063262334.1 → XP_063118404.1  inositol-tetrakisphosphate 1-kinase isoform X4

    4. XM_008764842.4 → XP_008763064.1  inositol-tetrakisphosphate 1-kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUY6
      Related
      ENSRNOP00000097242.1
      Conserved Domains (1) summary
      cl17255
      Location:7 → 327
      ATP-grasp_4; ATP-grasp domain

    5. XM_063262333.1 → XP_063118403.1  inositol-tetrakisphosphate 1-kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I6AUQ3
    Nucleotide Protein Strain
    Heading Accession and Version

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