Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdp2provided by RGD
Official Full Name: pyruvate dehydrogenase phosphatase catalytic subunit 2provided by RGD
Primary source: RGD:628812
See related: Ensembl:ENSRNOG00000012343 AllianceGenome:RGD:628812
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein serine/threonine phosphatase activity. Involved in peptidyl-threonine dephosphorylation and response to starvation. Located in mitochondrion. Orthologous to human PDP2 (pyruvate dehyrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 376.4), Liver (RPKM 172.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (392858..400529, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (386408..394068, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (597427..601556, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Starvation and diabetes reduce the amount of this enzyme in heart and kidney.
Title: Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney.

Submit: New GeneRIF Correction

General gene information

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Markers

Pdp2 (e-PCR), detects polymorphism
- UniSTS:526902

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T-helper cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial

Names: PDP 2; PDPC 2; pyruvate dehydrogenase phosphatase isoenzyme 2; pyruvate dehyrogenase phosphatase catalytic subunit 2

NP_659559.2

EC 3.1.3.43

XP_006255110.1

EC 3.1.3.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145091.4 → NP_659559.2 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

See identical proteins and their annotated locations for NP_659559.2

Status: VALIDATED

Source sequence(s)

BC072485

UniProtKB/Swiss-Prot

A0A0G2JSL7, O88484, Q6IN27

UniProtKB/TrEMBL

A6JXU9

Related

ENSRNOP00000016462.2, ENSRNOT00000016462.6

Conserved Domains (1) summary

smart00332
Location:96 → 516

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

392858..400529 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255048.5 → XP_006255110.1 pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006255110.1

UniProtKB/Swiss-Prot

A0A0G2JSL7, O88484, Q6IN27

UniProtKB/TrEMBL

A6JXU9

Conserved Domains (1) summary

smart00332
Location:96 → 516

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain