U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cryz crystallin zeta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362061, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cryzprovided by RGD
    Official Full Name
    crystallin zetaprovided by RGD
    Primary source
    RGD:1311639
    See related
    Ensembl:ENSRNOG00000028319 AllianceGenome:RGD:1311639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables mRNA 3'-UTR binding activity. Predicted to be involved in protein homotetramerization and xenobiotic catabolic process. Predicted to be active in cytosol. Orthologous to human CRYZ (crystallin zeta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1109.1) and Liver (RPKM 84.2) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cryz in Genome Data Viewer
    Location:
    2q45
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (246211707..246239472)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (243552037..243580369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260884315..260911827)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 20 Neighboring gene voltage-dependent anion channel 1, pseudogene 14 Neighboring gene 40S ribosomal protein S7 pseudogene Neighboring gene tRNA-yW synthesizing protein 3 homolog Neighboring gene uncharacterized LOC120100979 Neighboring gene uncharacterized LOC102555516 Neighboring gene glutamate-rich 3 Neighboring gene transmembrane protein 14C pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. pH-responsive stabilization of glutamate dehydrogenase mRNA in LLC-PK1-F+ cells. Schroeder JM, et al. Am J Physiol Renal Physiol, 2003 Aug. PMID 12684230
    2. Human and yeast zeta-crystallins bind AU-rich elements in RNA. Fernández MR, et al. Cell Mol Life Sci, 2007 Jun. PMID 17497241, Free PMC Article
    3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables NADH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables NADH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADPH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADPH:quinone reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH:quinone reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH:quinone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH:quinone reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    quinone oxidoreductase
    Names
    NADPH:quinone reductase
    crystallin, zeta (quinone reductase)
    zeta-crystallin
    NP_001012183.1
    XP_006233582.1
    XP_063138312.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012183.2 → NP_001012183.1  quinone oxidoreductase

      See identical proteins and their annotated locations for NP_001012183.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078927
      UniProtKB/Swiss-Prot
      Q6AYT0
      UniProtKB/TrEMBL
      A0A8I5Y5T4, A6HWQ3
      Related
      ENSRNOP00000038188.3, ENSRNOT00000032808.4
      Conserved Domains (2) summary
      cd08253
      Location:8 → 329
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
      COG0604
      Location:8 → 327
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      246211707..246239472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233520.5 → XP_006233582.1  quinone oxidoreductase isoform X1

      See identical proteins and their annotated locations for XP_006233582.1

      UniProtKB/Swiss-Prot
      Q6AYT0
      UniProtKB/TrEMBL
      A0A8I5Y5T4, A6HWQ3
      Conserved Domains (2) summary
      cd08253
      Location:8 → 329
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
      COG0604
      Location:8 → 327
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    2. XM_063282242.1 → XP_063138312.1  quinone oxidoreductase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYT0.1 GenPept UniProtKB/Swiss-Prot:Q6AYT0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous