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    Gmip Gem-interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306357, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gmipprovided by RGD
    Official Full Name
    Gem-interacting proteinprovided by RGD
    Primary source
    RGD:1565577
    See related
    Ensembl:ENSRNOG00000027257 AllianceGenome:RGD:1565577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565577
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular signal transduction; and negative regulation of GTPase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 89.2), Thymus (RPKM 64.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmip in Genome Data Viewer
    Location:
    16p14
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19634630..19648916, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19600723..19614459, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21349652..21363412, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene PBX homeobox 4 Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene ATPase 13A1 Neighboring gene zinc finger protein 709-like Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. Aresta S, et al. Biochem J, 2002 Oct 1. PMID 12093360, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GEM-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107308.1 → NP_001100778.1  GEM-interacting protein

      See identical proteins and their annotated locations for NP_001100778.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474031
      UniProtKB/TrEMBL
      A6KAB5, D3ZA46
      Related
      ENSRNOP00000034819.3, ENSRNOT00000039607.4
      Conserved Domains (3) summary
      smart00109
      Location:489 → 534
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:546 → 749
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:111 → 311
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19634630..19648916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252903.5 → XP_006252965.1  GEM-interacting protein isoform X1

      Conserved Domains (3) summary
      smart00109
      Location:486 → 531
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:543 → 746
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:111 → 311
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_039094492.2 → XP_038950420.1  GEM-interacting protein isoform X2

      Conserved Domains (3) summary
      cd20816
      Location:489 → 538
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:546 → 700
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:111 → 311
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_039094493.2 → XP_038950421.1  GEM-interacting protein isoform X3

      Conserved Domains (3) summary
      cd20816
      Location:489 → 538
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:546 → 626
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:111 → 311
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

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