Dab1 DAB adaptor protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dab1provided by RGD
Official Full Name: DAB adaptor protein 1provided by RGD
Primary source: RGD:628770
See related: Ensembl:ENSRNOG00000007410 AllianceGenome:RGD:628770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphatidylinositol 3-kinase binding activity. Involved in midgut development; nervous system development; and response to xenobiotic stimulus. Located in several cellular components, including brush border; neuronal cell body; and postsynaptic density. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 63.5), Liver (RPKM 8.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33-q34

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (123621510..124742585)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (118392953..119513625)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (123154360..124279170)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location.
Title: Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis.
Melatonin ameliorated the neurotoxiciy and astrocyte activation induced by Abeta1-42 in the cerebral cortex. Melatonin also blocked the reduction in Reelin and Dab1 expression induced by Abeta1-42. Using in vitro study, Reelin inactivation completely abolished the protective effect of melatonin against Abeta1-42-induced neurotoxicity.
Title: Neuroprotective effect of melatonin on soluble Aβ(1-42)-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway.
These results indicated that Dab1 mediated Ang II-induced podocyte apoptosis via p38 signaling pathway.
Title: Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes.
investigation of reelin-Disabled-1 signalling system in intestinal mucosa; Disabled-1 & VldlR protein signals were detected in the crypt and villus cells; they were particularly abundant in the terminal web domain of the enterocytes
Title: Rat small intestine expresses the reelin-Disabled-1 signalling pathway.
The present results suggest that disabled homolog 1 (Drosophila) disabled homolog 1 was affected by a number of different psychotropic medications commonly used to treat schizophrenia, bipolar disorder, major depression, and autism.
Title: Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats.
Fyn, due in part to its effects on Dab1, regulates the phosphorylation, trafficking, and processing of APP and apoEr2.
Title: Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing.
Dab1 was found to be localized to AII amacrine cells of the retina with lobular appendages in the outer half of the inner plexiform layer (IPL) and a bushy, smooth dendritic tree in the inner half of the IPL.
Title: AII amacrine cells in the mammalian retina show disabled-1 immunoreactivity.
Dab1 binds to PI3 kinase in response to Reelin signaling and is required for normal cortical lamination
Title: Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination.
An investigationi of how phosphoinositide binding by the Dab1 PTB domain influences Reelin signal transduction.
Title: Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU027053 (e-PCR)
- UniSTS:113677

d5rat96 (e-PCR)
- UniSTS:122173

D5Rat83 (e-PCR), detects polymorphism
- UniSTS:227970

Dab1 (e-PCR), detects polymorphism
- UniSTS:142824

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in astrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration	ISO Inferred from Sequence Orthology more info
involved_in cerebellum structural organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellum structural organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex cell migration	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex radially oriented cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in lateral motor column neuron migration	IEA Inferred from Electronic Annotation more info
involved_in lateral motor column neuron migration	ISO Inferred from Sequence Orthology more info
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within motor neuron migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in radial glia guided migration of Purkinje cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within radial glia guided migration of Purkinje cell	ISO Inferred from Sequence Orthology more info
involved_in radial glia-guided pyramidal neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within radial glia-guided pyramidal neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in ventral spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in ventral spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disabled homolog 1

Names: DAB1, reelin adaptor protein; Dab, reelin signal transducer, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411819.1 → NP_001398748.1 disabled homolog 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q8CJH2

UniProtKB/TrEMBL

A6JRT3

Related

ENSRNOP00000009977.1, ENSRNOT00000009977.3
NM_153621.2 → NP_705885.1 disabled homolog 1

See identical proteins and their annotated locations for NP_705885.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q8CJH2

UniProtKB/TrEMBL

A6JRT3

Conserved Domains (2) summary

PHA03247
Location:235 → 431

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

123621510..124742585

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109333.2 → XP_038965261.1 disabled homolog 1 isoform X2

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_039109335.2 → XP_038965263.1 disabled homolog 1 isoform X4

UniProtKB/TrEMBL

A0A0G2K0W1

Related

ENSRNOP00000071602.2

Conserved Domains (2) summary

PHA03247
Location:252 → 545

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_017593175.3 → XP_017448664.1 disabled homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8I5YBU9

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_017593177.3 → XP_017448666.1 disabled homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8I5YBU9

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_039109337.2 → XP_038965265.1 disabled homolog 1 isoform X7

Conserved Domains (2) summary

PHA03247
Location:200 → 396

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_063287212.1 → XP_063143282.1 disabled homolog 1 isoform X5
XM_039109334.2 → XP_038965262.1 disabled homolog 1 isoform X3

UniProtKB/Swiss-Prot

Q8CJH2

UniProtKB/TrEMBL

A6JRT3

Conserved Domains (2) summary

PHA03247
Location:235 → 431

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_039109338.2 → XP_038965266.1 disabled homolog 1 isoform X8

UniProtKB/TrEMBL

A0A8I6AAY7, A6JRT5

Related

ENSRNOP00000089729.1

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_017593178.3 → XP_017448667.1 disabled homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8I5YBU9

Related

ENSRNOP00000077479.1

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_063287216.1 → XP_063143286.1 disabled homolog 1 isoform X8

UniProtKB/TrEMBL

A0A8I6AAY7, A6JRT5
XM_063287213.1 → XP_063143283.1 disabled homolog 1 isoform X5
XM_063287214.1 → XP_063143284.1 disabled homolog 1 isoform X6

UniProtKB/TrEMBL

A0A8I6GBS3
XM_017593176.3 → XP_017448665.1 disabled homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8I5YBU9

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_063287210.1 → XP_063143280.1 disabled homolog 1 isoform X4

UniProtKB/TrEMBL

A0A0G2K0W1
XM_063287215.1 → XP_063143285.1 disabled homolog 1 isoform X8

UniProtKB/TrEMBL

A0A8I6AAY7, A6JRT5