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    Hook3 hook microtubule-tethering protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306548, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hook3provided by RGD
    Official Full Name
    hook microtubule-tethering protein 3provided by RGD
    Primary source
    RGD:1560960
    See related
    Ensembl:ENSRNOG00000014275 AllianceGenome:RGD:1560960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within several processes, including interkinetic nuclear migration; microtubule anchoring at centrosome; and neuronal stem cell population maintenance. Predicted to be located in centriolar satellite; cis-Golgi network; and pericentriolar material. Predicted to be part of FHF complex. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 322.0), Lung (RPKM 272.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hook3 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (72656929..72751696)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (65954293..66058812)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (70710347..70818789)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482515 Neighboring gene THAP domain containing 1 Neighboring gene ring finger protein 170 Neighboring gene farnesyltransferase, CAAX box, subunit alpha Neighboring gene protein-O-mannose kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3. Schroeder CM, et al. J Cell Biol, 2016 Aug 1. PMID 27482052, Free PMC Article
    2. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. Walenta JH, et al. J Cell Biol, 2001 Mar 5. PMID 11238449, Free PMC Article
    3. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. Sano H, et al. J Biol Chem, 2007 Mar 16. PMID 17237231
    4. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Ge X, et al. Neuron, 2010 Jan 28. PMID 20152126, Free PMC Article
    5. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hook3 interacts with a cytoplasmic domain of scavenger receptor A
      Title: The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynactin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein light chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within interkinetic nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule anchoring at centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Hook homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136098.1 → NP_001129570.1  protein Hook homolog 3

      See identical proteins and their annotated locations for NP_001129570.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/TrEMBL
      A0A8I5ZWS4, A0A8I6AQA0, A6IVZ4
      Related
      ENSRNOP00000091293.1, ENSRNOT00000097055.1
      Conserved Domains (2) summary
      pfam05622
      Location:184 → 709
      HOOK; HOOK protein
      cl41774
      Location:8 → 160
      HkD_SF; Hook domain-containing proteins superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      72656929..72751696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094555.2 → XP_038950483.1  protein Hook homolog 3 isoform X1

      Conserved Domains (2) summary
      pfam05622
      Location:184 → 546
      HOOK; HOOK protein
      cd22226
      Location:8 → 160
      HkD_Hook3; Hook domain found in protein Hook 3 (Hook3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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