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    Plcd4 phospholipase C, delta 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140693, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Plcd4provided by RGD
    Official Full Name
    phospholipase C, delta 4provided by RGD
    Primary source
    RGD:621025
    See related
    Ensembl:ENSRNOG00000016361 AllianceGenome:RGD:621025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling and small GTPase mediated signal transduction. Predicted to act upstream of or within acrosome reaction. Predicted to be located in cytosol; endoplasmic reticulum; and plasma membrane. Orthologous to human PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 118.8), Testes (RPKM 71.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83564616..83613742)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76115523..76158602)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81816395..81844364)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 37 Neighboring gene transfer RNA proline (anticodon AGG) 59 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene serine/threonine kinase 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel phospholipase C delta4 (PLCdelta4) splice variant as a negative regulator of PLC. Nagano K, et al. J Biol Chem, 1999 Jan 29. PMID 9915823
    2. A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. Liu N, et al. J Biol Chem, 1996 Jan 5. PMID 8550586
    3. Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4. Lee SB, et al. J Biol Chem, 1996 Jan 5. PMID 8550568
    4. Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction. Fukami K, et al. Science, 2001 May 4. PMID 11340203
    5. A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins. Maziarz M, et al. J Biol Chem, 2018 Nov 2. PMID 30194280, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome reaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Names
    PLC-delta-4
    phosphoinositide phospholipase C-delta-4
    NP_542419.1
    XP_006245198.1
    XP_006245199.1
    XP_006245200.1
    XP_008765404.1
    XP_008765406.1
    XP_008765409.1
    XP_008765410.1
    XP_008765411.1
    XP_008765412.1
    XP_038938901.1
    XP_038938902.1
    XP_038938903.1
    XP_063122672.1
    XP_063122673.1
    XP_063122674.1
    XP_063122675.1
    XP_063122676.1
    XP_063122677.1
    XP_063122678.1
    XP_063122679.1
    XP_063122680.1
    XP_063122681.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080688.1 → NP_542419.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

      See identical proteins and their annotated locations for NP_542419.1

      Status: PROVISIONAL

      Source sequence(s)
      U16655
      UniProtKB/Swiss-Prot
      Q62711, Q63693
      UniProtKB/TrEMBL
      A0A8L2QKX9
      Related
      ENSRNOP00000039708.3, ENSRNOT00000041407.5
      Conserved Domains (8) summary
      cd00275
      Location:636 → 761
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02228
      Location:207 → 749
      PLN02228; Phosphoinositide phospholipase C
      pfam00169
      Location:17 → 123
      PH; PH domain
      pfam09279
      Location:207 → 289
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:175 → 231
      EF-hand_7; EF-hand domain pair
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 606
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83564616..83613742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767187.4 → XP_008765409.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (8) summary
      cd00275
      Location:667 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02228
      Location:207 → 775
      PLN02228; Phosphoinositide phospholipase C
      pfam00169
      Location:17 → 123
      PH; PH domain
      pfam09279
      Location:207 → 289
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:175 → 231
      EF-hand_7; EF-hand domain pair
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 637
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    2. XM_063266604.1 → XP_063122674.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4

    3. XM_008767184.4 → XP_008765406.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_008765406.1

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 776
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    4. XM_063266602.1 → XP_063122672.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    5. XM_039082973.2 → XP_038938901.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 776
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    6. XM_008767188.4 → XP_008765410.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (8) summary
      cd00275
      Location:650 → 801
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02228
      Location:207 → 758
      PLN02228; Phosphoinositide phospholipase C
      pfam00169
      Location:17 → 123
      PH; PH domain
      pfam09279
      Location:207 → 289
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:175 → 231
      EF-hand_7; EF-hand domain pair
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 620
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    7. XM_063266608.1 → XP_063122678.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X8

    8. XM_039082975.2 → XP_038938903.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 781
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    9. XM_063266605.1 → XP_063122675.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

    10. XM_008767189.4 → XP_008765411.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 781
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    11. XM_063266607.1 → XP_063122677.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X7

    12. XM_063266606.1 → XP_063122676.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

    13. XM_008767190.4 → XP_008765412.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (8) summary
      cd00275
      Location:636 → 787
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02228
      Location:207 → 744
      PLN02228; Phosphoinositide phospholipase C
      pfam00169
      Location:17 → 123
      PH; PH domain
      pfam09279
      Location:207 → 289
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:175 → 231
      EF-hand_7; EF-hand domain pair
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 606
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    14. XM_063266611.1 → XP_063122681.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X10

    15. XM_063266610.1 → XP_063122680.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X9

      UniProtKB/Swiss-Prot
      Q62711, Q63693

    16. XM_063266609.1 → XP_063122679.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X9

      UniProtKB/Swiss-Prot
      Q62711, Q63693

    17. XM_008767182.4 → XP_008765404.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_008765404.1

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 776
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    18. XM_006245136.5 → XP_006245198.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006245198.1

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 776
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    19. XM_006245137.5 → XP_006245199.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006245199.1

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 776
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    20. XM_063266603.1 → XP_063122673.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    21. XM_006245138.5 → XP_006245200.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006245200.1

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 776
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    22. XM_039082974.2 → XP_038938902.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QKX9
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 776
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 638
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62711.1 GenPept UniProtKB/Swiss-Prot:Q62711

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