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    Camlg calcium modulating ligand [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81715, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Camlgprovided by RGD
    Official Full Name
    calcium modulating ligandprovided by RGD
    Primary source
    RGD:69297
    See related
    Ensembl:ENSRNOG00000021911 AllianceGenome:RGD:69297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Caml
    Summary
    Enables cell adhesion molecule binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Orthologous to human CAMLG (calcium modulating ligand). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 57.1), Brain (RPKM 56.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (8997868..9009140, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (8992697..9003576, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9523792..9534683, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 5 open reading frame 24 Neighboring gene DEAD-box helicase 46 Neighboring gene transfer RNA serine (anticodon AGA) 29 Neighboring gene beta-1,4-galactosyltransferase 7 Neighboring gene transmembrane p24 trafficking protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of rat calcium-modulating cyclophilin ligand. Lee SJ, et al. DNA Seq, 2001. PMID 11762198
    2. Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells. Brandenburg LO, et al. J Neuroimmunol, 2009 Dec 10. PMID 19879657
    3. TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain. Lan X, et al. Sci Rep, 2018 Jul 2. PMID 29967478, Free PMC Article
    4. IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway. Liu M, et al. Int J Mol Med, 2012 Jun. PMID 22426572
    5. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. Yamamoto Y, et al. Mol Cell, 2012 Nov 9. PMID 23041287

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAML role in the hepatocyte proliferation.TMUB1 regulates hepatocyte proliferation by interacting with CAML and further interferes with the binding of CAML to cyclophilin B.
      Title: TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GET complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of GET complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    guided entry of tail-anchored proteins factor CAMLG
    Names
    calcium signal-modulating cyclophilin ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398726.1 → NP_001385655.1  guided entry of tail-anchored proteins factor CAMLG isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      F7FMD6, Q6DGG9, Q9ERK1
      Conserved Domains (1) summary
      pfam14963
      Location:21 → 291
      CAML; Calcium signal-modulating cyclophilin ligand

    2. NM_053334.2 → NP_445786.2  guided entry of tail-anchored proteins factor CAMLG isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8L2QHI2
      Related
      ENSRNOP00000033945.6, ENSRNOT00000037088.6
      Conserved Domains (1) summary
      pfam14963
      Location:21 → 290
      CAML; Calcium signal-modulating cyclophilin ligand

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      8997868..9009140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253659.5 → XP_006253721.1  guided entry of tail-anchored proteins factor CAMLG isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH13
      Related
      ENSRNOP00000092138.1
      Conserved Domains (1) summary
      pfam14963
      Location:21 → 269
      CAML; Calcium signal-modulating cyclophilin ligand

    2. XM_063276772.1 → XP_063132842.1  guided entry of tail-anchored proteins factor CAMLG isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DGG9.1 GenPept UniProtKB/Swiss-Prot:Q6DGG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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