Slc8a2 solute carrier family 8 member A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc8a2provided by RGD
Official Full Name: solute carrier family 8 member A2provided by RGD
Primary source: RGD:620194
See related: Ensembl:ENSRNOG00000001492 AllianceGenome:RGD:620194
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ncx2
Summary: Enables calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Involved in inorganic cation transmembrane transport; response to vitamin D; and telencephalon development. Acts upstream of or within cellular calcium ion homeostasis. Located in several cellular components, including dendritic spine; microtubule; and neuronal cell body. Is active in postsynapse. Is integral component of mitochondrial membrane and integral component of postsynaptic membrane. Biomarker of brain ischemia and status epilepticus. Orthologous to human SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 340.5) and Uterus (RPKM 29.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (85944752..85982900)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (76816583..76852928)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78029555..78054042)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage?
Title: Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage?
Identification and characterization of the promoter and transcription factors regulating the expression of cerebral sodium/calcium exchanger 2 (NCX2) gene.
Title: Identification and characterization of the promoter and transcription factors regulating the expression of cerebral sodium/calcium exchanger 2 (NCX2) gene.
Data show a general mechanism for regulatory coupling associated with Ca2+ interactions with regulatory CBD domains of NCX1, NCX2, and NCX3 isoforms and their splice variants, where the dynamic effects of alternative splicing on conformational dynamics of the two-domain regulatory tandem (CBD12) control the contribution of a given isoform/splice variant to dynamic handling of cytosolic Ca2+ oscillations in many cell type.
Title: Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.
analyze the equilibrium and kinetic properties of Ca(2+) binding to purified preparations of CBD1, CBD2, and CBD12 from NCX2 and from NCX3 splice variants
Title: Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.
This study showed that normobaric hyperoxia changes the patterns of expression NCX2 in the penumbra and spinal cordcore.
Title: Effects of preconditioning with normobaric hyperoxia on Na⁺/Ca²⁺ exchanger in the rat brain.
NCX isoforms (NCX1, NCX2, and NCX3) were expressed in primary cultured rat trigeminal ganglion neurons.
Title: Sodium-calcium exchangers in rat trigeminal ganglion neurons.
High levels of NCX2 overexpression increase neuronal survival following hypoxia-ischemia and improve neuronal calcium management.
Title: High level over-expression of different NCX isoforms in HEK293 cell lines and primary neuronal cultures is protective following oxygen glucose deprivation.
The presence of NCX2, together with multiple sodium channel isoforms, in free nerve endings may have important functional implications.
Title: Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals.
Taken together, our results show that NCX subtype protein expression is sensitive to cerebral ischemia, and indicates that changes in NCX activity may be playing an important role in calcium maintenance and neuronal outcome following ischemia.
Title: Na+/Ca2+ exchanger subtype (NCX1, NCX2, NCX3) protein expression in the rat hippocampus following 3 min and 8 min durations of global cerebral ischemia.
plasma membrane Na+/Ca2+ exchangers have inhibitory interactions with the 14-3-3 proteins
Title: Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE106527 (e-PCR)
- UniSTS:246302

RH137848 (e-PCR)
- UniSTS:219935

D1Got72 (e-PCR)
- UniSTS:115422

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	NAS Non-traceable Author Statement more info	PubMed
enables calcium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium:sodium antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium:sodium antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables calcium:sodium antiporter activity	TAS Traceable Author Statement more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in calcium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in learning	IEA Inferred from Electronic Annotation more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in learning	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within modulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential firing pattern	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of action potential firing pattern	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcineurin-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of calcineurin-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of short-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in telencephalon development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/calcium exchanger 2

Names: Na(+)/Ca(2+)-exchange protein 2; solute carrier family 8 (sodium/calcium exchanger), member 2; solute carrier family 8 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_078619.2 → NP_511174.2 sodium/calcium exchanger 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P48768

UniProtKB/TrEMBL

A0A0G2JZK7, A6J898

Conserved Domains (1) summary

TIGR00845
Location:1 → 921

caca; sodium/calcium exchanger 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

85944752..85982900

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080746.2 → XP_038936674.1 sodium/calcium exchanger 2 isoform X3

UniProtKB/Swiss-Prot

P48768

Conserved Domains (1) summary

TIGR00845
Location:1 → 852

caca; sodium/calcium exchanger 1
XM_039080711.2 → XP_038936639.1 sodium/calcium exchanger 2 isoform X1

UniProtKB/Swiss-Prot

P48768

UniProtKB/TrEMBL

A0A0G2JZK7, A6J898

Related

ENSRNOP00000071086.2

Conserved Domains (1) summary

TIGR00845
Location:1 → 921

caca; sodium/calcium exchanger 1
XM_063270123.1 → XP_063126193.1 sodium/calcium exchanger 2 isoform X4
XM_063270095.1 → XP_063126165.1 sodium/calcium exchanger 2 isoform X2

UniProtKB/TrEMBL

F1M9A2