Gmfb glia maturation factor, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gmfbprovided by RGD
Official Full Name: glia maturation factor, betaprovided by RGD
Primary source: RGD:70910
See related: Ensembl:ENSRNOG00000064480 AllianceGenome:RGD:70910
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within learning and locomotory behavior. Orthologous to human GMFB (glia maturation factor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 436.7), Adrenal (RPKM 358.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (22549705..22560125, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (20069923..20081005, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (23597846..23611541, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model.
Title: GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model.
Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity.
Title: Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity.
This study demonstrated that GMFB is up-regulated in astrocytes after Acute Cerebral Ischemia.
Title: Brain-Derived Glia Maturation Factor β Participates in Lung Injury Induced by Acute Cerebral Ischemia by Increasing ROS in Endothelial Cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE095473 (e-PCR)
- UniSTS:243459

Gmfb (e-PCR), detects polymorphism
- UniSTS:534572

RH132322 (e-PCR)
- UniSTS:215605

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables Arp2/3 complex binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament debranching	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament debranching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glia maturation factor beta

Names: DNA for thyroid hormone receptor binding site (276bp); GMF-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031032.2 → NP_112294.1 glia maturation factor beta

See identical proteins and their annotated locations for NP_112294.1

Status: PROVISIONAL

Source sequence(s)

BC081778

UniProtKB/Swiss-Prot

Q63228

UniProtKB/TrEMBL

A6KE25, M0RDJ4

Related

ENSRNOP00000089942.1, ENSRNOT00000101993.1

Conserved Domains (1) summary

cd11283
Location:9 → 130

ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins