Lcmt1 leucine carboxyl methyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lcmt1provided by RGD
Official Full Name: leucine carboxyl methyltransferase 1provided by RGD
Primary source: RGD:735118
See related: Ensembl:ENSRNOG00000014565 AllianceGenome:RGD:735118
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein C-terminal leucine carboxyl O-methyltransferase activity. Predicted to be involved in C-terminal protein methylation. Predicted to act upstream of or within several processes, including protein methylation; regulation of glucose metabolic process; and regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be active in cytosol. Orthologous to human LCMT1 (leucine carboxyl methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 171.4), Brain (RPKM 163.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (187335173..187391195)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (177904119..177960111)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (193335629..193391620)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
Title: HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
A dominant-negative LCMT-1 mutant attenuates the cell cycle without causing cell death, likely by inhibiting uncontrolled phosphatase activity
Title: The structural basis for tight control of PP2A methylation and function by LCMT-1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein C-terminal carboxyl O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein C-terminal carboxyl O-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein C-terminal leucine carboxyl O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in C-terminal protein methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine carboxyl methyltransferase 1

Names: [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

NP_955437.2

EC 2.1.1.233

XP_006230253.1

EC 2.1.1.233

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199405.3 → NP_955437.2 leucine carboxyl methyltransferase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q6P4Z6

UniProtKB/TrEMBL

A6I901

Related

ENSRNOP00000019640.4, ENSRNOT00000019640.5

Conserved Domains (1) summary

pfam04072
Location:24 → 215

LCM; Leucine carboxyl methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

187335173..187391195

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230191.5 → XP_006230253.1 leucine carboxyl methyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A6V3

Related

ENSRNOP00000087959.1

Conserved Domains (1) summary

pfam04072
Location:24 → 215

LCM; Leucine carboxyl methyltransferase