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    Slc16a12 solute carrier family 16, member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309525, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Slc16a12provided by RGD
    Official Full Name
    solute carrier family 16, member 12provided by RGD
    Primary source
    RGD:1311468
    See related
    Ensembl:ENSRNOG00000021916 AllianceGenome:RGD:1311468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCT 12; RGD1311468
    Summary
    Predicted to enable creatine transmembrane transporter activity and monocarboxylic acid transmembrane transporter activity. Predicted to be involved in creatine transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 986.0), Liver (RPKM 342.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q53
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241597165..241674821, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (232184004..232262170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252976071..253054500, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA71 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1B-like Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC134485224 Neighboring gene pantothenate kinase 1 Neighboring gene microRNA 107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney. Verouti SN, et al. Am J Physiol Renal Physiol, 2021 Mar 1. PMID 33459166
    2. Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells. Jomura R, et al. Biochim Biophys Acta Biomembr, 2020 Nov 1. PMID 32781157
    3. Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes. Jomura R, et al. Am J Physiol Gastrointest Liver Physiol, 2021 Aug 1. PMID 34075817
    4. The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter. Abplanalp J, et al. Hum Mol Genet, 2013 Aug 15. PMID 23578822, Free PMC Article
    5. Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane. Castorino JJ, et al. Invest Ophthalmol Vis Sci, 2011 Aug 29. PMID 21778275, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney.
      Title: Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney.
    2. Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells.
      Title: Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells.
    3. a model whereby the SLC16A12 (c.643C>T) mutation causes juvenile cataract by a defect in protein trafficking rather than by haploinsufficiency.
      Title: Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables creatine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables creatine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uniporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uniporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in creatine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in creatine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in creatine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in creatinine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 12
    Names
    solute carrier family 16 (monocarboxylic acid transporters), member 12
    solute carrier family 16, member 12 (monocarboxylic acid transporter 12)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191637.1 → NP_001178566.1  monocarboxylate transporter 12

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D4A734
      Conserved Domains (1) summary
      cl26868
      Location:12 → 451
      2A0111; oxalate/formate antiporter family transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      241597165..241674821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589301.3 → XP_017444790.1  monocarboxylate transporter 12 isoform X1

      UniProtKB/Swiss-Prot
      D4A734
      Conserved Domains (1) summary
      cl26868
      Location:12 → 451
      2A0111; oxalate/formate antiporter family transporter

    2. XM_017589300.3 → XP_017444789.1  monocarboxylate transporter 12 isoform X1

      UniProtKB/Swiss-Prot
      D4A734
      Related
      ENSRNOP00000038838.3
      Conserved Domains (1) summary
      cl26868
      Location:12 → 451
      2A0111; oxalate/formate antiporter family transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A734.1 GenPept UniProtKB/Swiss-Prot:D4A734

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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