Mmp19 matrix metallopeptidase 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mmp19provided by RGD
Official Full Name: matrix metallopeptidase 19provided by RGD
Primary source: RGD:1311376
See related: Ensembl:ENSRNOG00000006778 AllianceGenome:RGD:1311376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity. Involved in female gonad development; response to cAMP; and response to hormone. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP19 (matrix metallopeptidase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 168.9), Adrenal (RPKM 110.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1805732..1814054)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (1221229..1229555)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (3216392..3224202)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The induction of MMP-19 mRNA suggests an important role of this proteinase during follicular growth, ovulation, and luteal regression.
Title: Regulation of matrix metalloproteinase-19 messenger RNA expression in the rat ovary.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
involved_in ovarian follicle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ovulation from ovarian follicle	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: matrix metalloproteinase-19

Names: MMP-19; matrix metalloproteinase 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107159.3 → NP_001100629.1 matrix metalloproteinase-19 precursor

See identical proteins and their annotated locations for NP_001100629.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6KSI7, C0M4B0, F7EUD4

Related

ENSRNOP00000008909.4, ENSRNOT00000008909.8

Conserved Domains (3) summary

cd00094
Location:286 → 471

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:105 → 257

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:27 → 81

PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1805732..1814054

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240758.4 → XP_006240820.1 matrix metalloproteinase-19 isoform X1

Conserved Domains (3) summary

cd00094
Location:214 → 399

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:33 → 185

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:32 → 185

Peptidase_M10; Matrixin
XM_039078969.2 → XP_038934897.1 matrix metalloproteinase-19 isoform X2

Conserved Domains (3) summary

cd04278
Location:105 → 257

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:27 → 81

PG_binding_1; Putative peptidoglycan binding domain

cl02471
Location:286 → 354

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...