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    Luc7l LUC7-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360503, updated on 25-Apr-2024

    Summary

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    Symbol
    Luc7lprovided by RGD
    Full Name
    LUC7-likeprovided by RGD
    Primary source
    RGD:1307542
    See related
    Ensembl:ENSRNOG00000020488 AllianceGenome:RGD:1307542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Luc7l1
    Summary
    Predicted to enable RS domain binding activity; identical protein binding activity; and mRNA binding activity. Predicted to be involved in mRNA splice site selection. Predicted to act upstream of or within negative regulation of striated muscle tissue development. Predicted to be located in nucleus. Predicted to be part of U1 snRNP and U2-type prespliceosome. Orthologous to human LUC7L (LUC7 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 112.1), Thymus (RPKM 102.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Luc7l in Genome Data Viewer
    Location:
    10q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15777837..15811586)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15273340..15307131)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15538878..15572651)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234, member A Neighboring gene uncharacterized LOC108352066 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene small nucleolar RNA U13 Neighboring gene hemoglobin alpha, adult chain 3 Neighboring gene hemoglobin, theta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serine-arginine-rich nuclear protein Luc7l regulates myogenesis in mice. Kimura E, et al. Gene, 2004 Oct 27. PMID 15474286
    2. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Cazalla D, et al. Mol Cell Biol, 2005 Apr. PMID 15798186, Free PMC Article
    3. Dynamic protein-protein interaction wiring of the human spliceosome. Hegele A, et al. Mol Cell, 2012 Feb 24. PMID 22365833
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RS domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative RNA-binding protein Luc7-like 1
    Names
    LUC7-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399674.1 → NP_001386603.1  putative RNA-binding protein Luc7-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HDA0, G3V9R0, Q5FVI7
      Related
      ENSRNOP00000056826.4, ENSRNOT00000060078.5

    2. NM_001399675.1 → NP_001386604.1  putative RNA-binding protein Luc7-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A458, A6HDA1
      Related
      ENSRNOP00000087424.1, ENSRNOT00000109984.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15777837..15811586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086288.2 → XP_038942216.1  putative RNA-binding protein Luc7-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2QBZ8
      Conserved Domains (1) summary
      pfam03194
      Location:5 → 242
      LUC7; LUC7 N_terminus

    2. XM_017597369.3 → XP_017452858.1  putative RNA-binding protein Luc7-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2QBZ8
      Conserved Domains (1) summary
      pfam03194
      Location:1 → 189
      LUC7; LUC7 N_terminus

    3. XM_063269322.1 → XP_063125392.1  putative RNA-binding protein Luc7-like 1 isoform X2

    4. XM_039086289.2 → XP_038942217.1  putative RNA-binding protein Luc7-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2QBZ8
      Conserved Domains (1) summary
      pfam03194
      Location:1 → 189
      LUC7; LUC7 N_terminus

    5. XM_039086291.2 → XP_038942219.1  putative RNA-binding protein Luc7-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2QBZ8
      Conserved Domains (1) summary
      cl27291
      Location:1 → 156
      LUC7; LUC7 N_terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024269.1: Suppressed sequence

      Description
      NM_001024269.1: This RefSeq was removed because currently there is insufficient support for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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