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    Gna14 G protein subunit alpha 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309242, updated on 2-May-2024

    Summary

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    Official Symbol
    Gna14provided by RGD
    Official Full Name
    G protein subunit alpha 14provided by RGD
    Primary source
    RGD:1308122
    See related
    Ensembl:ENSRNOG00000014840 AllianceGenome:RGD:1308122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg1i; Tieg3
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNA14 (G protein subunit alpha 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 97.2), Kidney (RPKM 40.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (223141802..223324210)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (213714993..213900083)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (235165775..235347986)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene PWP1 homolog, endonuclein, pseudogene 2 Neighboring gene eukaryotic translation initiation factor 2 subunit beta, pseudogene 1 Neighboring gene vacuolar protein sorting 13 homolog A Neighboring gene forkhead box B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular properties of muscarinic acetylcholine receptors. Haga T. Proc Jpn Acad Ser B Phys Biol Sci, 2013. PMID 23759942, Free PMC Article
    2. Regulation of phosphoinositide-specific phospholipase C. Rhee SG. Annu Rev Biochem, 2001. PMID 11395409, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105546

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein subunit alpha-14
    Names
    TGFB inducible early growth response 3
    guanine nucleotide binding protein, alpha 14
    heterotrimeric guanine nucleotide-binding protein 1i

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013151.2 → NP_001013169.1  guanine nucleotide-binding protein subunit alpha-14

      See identical proteins and their annotated locations for NP_001013169.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8J8XRQ3, F1LRE6, Q5EAP4
      Related
      ENSRNOP00000020201.7, ENSRNOT00000020201.8
      Conserved Domains (2) summary
      cd00066
      Location:36 → 349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:16 → 353
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      223141802..223324210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760288.4 → XP_008758510.1  guanine nucleotide-binding protein subunit alpha-14 isoform X1

      See identical proteins and their annotated locations for XP_008758510.1

      UniProtKB/TrEMBL
      A0A8J8XRQ3, F1LRE6, Q5EAP4
      Conserved Domains (2) summary
      cd00066
      Location:36 → 349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:16 → 353
      G_alpha; G protein alpha subunit
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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