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    Ddhd1 DDHD domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305816, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ddhd1provided by RGD
    Official Full Name
    DDHD domain containing 1provided by RGD
    Primary source
    RGD:1308576
    See related
    Ensembl:ENSRNOG00000009481 AllianceGenome:RGD:1308576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipase activity. Predicted to act upstream of or within positive regulation of mitochondrial fission and sperm mitochondrion organization. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 28. Orthologous to human DDHD1 (DDHD domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 135.8), Brain (RPKM 77.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddhd1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (21304053..21370608, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18824389..18891036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19963639..20032263, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10-like 6 Neighboring gene U6 spliceosomal RNA Neighboring gene FERM domain containing kindlin 2 Neighboring gene ribosomal protein S29, pseudogene 19 Neighboring gene uncharacterized LOC108352894 Neighboring gene uncharacterized LOC108352895 Neighboring gene uncharacterized LOC134481954

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. Baba T, et al. J Biol Chem, 2014 Apr 18. PMID 24599962, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125147

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase DDHD1
    NP_001028238.1
    XP_006251831.1
    XP_006251832.1
    XP_006251834.1
    XP_006251835.1
    XP_006251836.1
    XP_038949183.1
    XP_038949185.1
    XP_063130275.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033066.2 → NP_001028238.1  phospholipase DDHD1

      See identical proteins and their annotated locations for NP_001028238.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      Q3ZAU5
      Related
      ENSRNOP00000035399.4, ENSRNOT00000032704.6
      Conserved Domains (1) summary
      pfam02862
      Location:597 → 840
      DDHD; DDHD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      21304053..21370608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251773.5 → XP_006251835.1  phospholipase DDHD1 isoform X6

      Conserved Domains (1) summary
      pfam02862
      Location:597 → 868
      DDHD; DDHD domain

    2. XM_063274205.1 → XP_063130275.1  phospholipase DDHD1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZSB2

    3. XM_006251770.5 → XP_006251832.1  phospholipase DDHD1 isoform X2

      Conserved Domains (1) summary
      pfam02862
      Location:631 → 902
      DDHD; DDHD domain

    4. XM_006251774.5 → XP_006251836.1  phospholipase DDHD1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ADX7
      Related
      ENSRNOP00000092577.1
      Conserved Domains (1) summary
      pfam02862
      Location:604 → 847
      DDHD; DDHD domain

    5. XM_006251772.5 → XP_006251834.1  phospholipase DDHD1 isoform X4

      Conserved Domains (1) summary
      pfam02862
      Location:604 → 875
      DDHD; DDHD domain

    6. XM_039093255.2 → XP_038949183.1  phospholipase DDHD1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AX45
      Related
      ENSRNOP00000093499.1
      Conserved Domains (1) summary
      pfam02862
      Location:638 → 881
      DDHD; DDHD domain

    7. XM_006251769.5 → XP_006251831.1  phospholipase DDHD1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZK24
      Related
      ENSRNOP00000076372.1
      Conserved Domains (1) summary
      pfam02862
      Location:638 → 909
      DDHD; DDHD domain

    8. XM_039093257.2 → XP_038949185.1  phospholipase DDHD1 isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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