Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Papss2provided by RGD
Official Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by RGD
Primary source: RGD:1307012
See related: Ensembl:ENSRNOG00000011068 AllianceGenome:RGD:1307012
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Predicted to act upstream of or within blood coagulation and bone development. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 267.4), Kidney (RPKM 113.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (239867597..239952614)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (230454314..230539332)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (251145264..251230716)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU047720 (e-PCR)
- UniSTS:110230

D1Rat446 (e-PCR)
- UniSTS:227228

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylylsulfate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylylsulfate kinase activity	ISO Inferred from Sequence Orthology more info
enables selenate adenylyltransferase (ATP) activity	TAS Traceable Author Statement more info
enables sulfate adenylyltransferase (ATP) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sulfate assimilation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate assimilation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sulfate assimilation	ISO Inferred from Sequence Orthology more info
involved_in sulfate assimilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

NP_001099845.2

EC 2.7.1.25

EC 2.7.7.4

XP_006231336.1

EC 2.7.1.25

EC 2.7.7.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106375.2 → NP_001099845.2 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

See identical proteins and their annotated locations for NP_001099845.2

Status: PROVISIONAL

Source sequence(s)

BC169061

UniProtKB/TrEMBL

B5DFH4

Related

ENSRNOP00000014979.4, ENSRNOT00000014979.6

Conserved Domains (3) summary

cd00517
Location:243 → 606

ATPS; ATP-sulfurylase

cd02027
Location:43 → 193

APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

TIGR00339
Location:225 → 605

sopT; ATP sulphurylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

239867597..239952614

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231274.5 → XP_006231336.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K950

Related

ENSRNOP00000074860.1

Conserved Domains (3) summary

cd00517
Location:243 → 611

ATPS; ATP-sulfurylase

cd02027
Location:43 → 193

APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

TIGR00339
Location:225 → 610

sopT; ATP sulphurylase