Rln3 relaxin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rln3provided by RGD
Official Full Name: relaxin 3provided by RGD
Primary source: RGD:628745
See related: Ensembl:ENSRNOG00000005911 AllianceGenome:RGD:628745
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Insl7
Summary: Enables G protein-coupled receptor binding activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Orthologous to human RLN3 (relaxin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 4.6), Brain (RPKM 2.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (41012168..41014199)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24107401..24109432)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25164497..25166528, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endurance exercise improves avoidance learning and spatial memory, through changes in genes of GABA and relaxin-3, in rats.
Title: Endurance exercise improves avoidance learning and spatial memory, through changes in genes of GABA and relaxin-3, in rats.
RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior.
Title: RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior.
Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats.
Title: Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats.
Study shows that relaxin-3 regulates corticotropin-releasing factor gene expression in cultured rat hypothalamic 4B cells. Results suggest that the action of relaxin-3 in cultured hypothalamic 4B cells may be regulated through both RXFP1 and RXFP3.
Title: Relaxin-3 regulates corticotropin-releasing factor gene expression in cultured rat hypothalamic 4B cells.
Data suggest activation of the nucleus incertus relaxin-3 system is associated with expression of behavior in tests of anxiety, but may not be directly involved in the approach-avoidance conflict inherent in anxiety-related defensive behavior in rodents.
Title: Involvement of Serotonergic and Relaxin-3 Neuropeptide Systems in the Expression of Anxiety-like Behavior.
Nur77-induced RLN3 expression is an important mediator for the suppression of cardiomyocyte apoptosis
Title: Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes.
Relaxin-1 mRNA in the hearts of diabetic rats was significantly increased and that relaxin-3 mRNA expression at different time points was decreased. In addition, significant down-regulation of the mRNA expression of RXFP1 and RXFP3 was observed at 4 weeks after Streptozocin.
Title: Alterations of relaxin and its receptor system components in experimental diabetic cardiomyopathy rats.
Relaxin-3/RXFP3 signaling within the central amygdala contributes to yohimbine-induced reinstatement of alcohol seeking. We therefore suggest that the relaxin-3/RXFP3 system represents a legitimate potential target for the treatment of both anxiety and substance use disorders.
Title: Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats.
Study demonstrates that female rats are more sensitive to the effects of chronic i.c.v. infusion of relaxin-3 (RLN3) on body weight, fat mass and food intake compared to male rats. Female RLN3-infused rats displayed higher body weight gain and perigonadal fat mass and more sustained hyperphagia than male rats during 14 days of treatment.
Title: Sex-Specific Effects of Chronic Administration of Relaxin-3 on Food Intake, Body Weight and the Hypothalamic-Pituitary-Gonadal Axis in Rats.
food intake response stronger in females
Title: Sex-specific effects of relaxin-3 on food intake and brain expression of corticotropin-releasing factor in rats.

Submit: New GeneRIF Correction See all GeneRIFs (27)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: relaxin-3

Names: insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7; prorelaxin R3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_170667.2 → NP_733767.1 relaxin-3 precursor

See identical proteins and their annotated locations for NP_733767.1

Status: PROVISIONAL

Source sequence(s)

AB076564

UniProtKB/Swiss-Prot

Q8BFS3

UniProtKB/TrEMBL

A6IYB3

Related

ENSRNOP00000007775.1, ENSRNOT00000007775.5

Conserved Domains (1) summary

cd04365
Location:29 → 140

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...