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    Stfa3 stefin A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288075, updated on 29-Feb-2024

    Summary

    Official Symbol
    Stfa3provided by RGD
    Official Full Name
    stefin A3provided by RGD
    Primary source
    RGD:1307831
    See related
    Ensembl:ENSRNOG00000033933 AllianceGenome:RGD:1307831
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Csta
    Summary
    Predicted to be involved in negative regulation of endopeptidase activity. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 379.3) See more
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    Genomic context

    See Stfa3 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77859070..77864212)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64353722..64358864)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67309046..67314181)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene CD86 molecule Neighboring gene uncharacterized LOC134481008 Neighboring gene calcium-sensing receptor Neighboring gene U6 spliceosomal RNA Neighboring gene cystatin A family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    cystatin-A
    Names
    cystatin-alpha
    epidermal stefin
    epidermal thiol proteinase inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105877.1NP_001099347.1  cystatin-A

      See identical proteins and their annotated locations for NP_001099347.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473967
      UniProtKB/Swiss-Prot
      P01039
      UniProtKB/TrEMBL
      A6IRD0
      Related
      ENSRNOP00000043059.3, ENSRNOT00000051936.5
      Conserved Domains (1) summary
      pfam00031
      Location:1097
      Cystatin; Cystatin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      77859070..77864212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)