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    Denr density-regulated protein [ Mus musculus (house mouse) ]

    Gene ID: 68184, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Denrprovided by MGI
    Official Full Name
    density-regulated proteinprovided by MGI
    Primary source
    MGI:MGI:1915434
    See related
    Ensembl:ENSMUSG00000023106 AllianceGenome:MGI:1915434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500003K04Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to act upstream of or within translational initiation. Is expressed in embryo. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 21.0), liver E14 (RPKM 12.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 63.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124045309..124066705)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123907205..123928832)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene hydrocarboxylic acid receptor 1 Neighboring gene STARR-seq mESC enhancer starr_14329 Neighboring gene STARR-positive B cell enhancer ABC_E4789 Neighboring gene STARR-positive B cell enhancer ABC_E6379 Neighboring gene STARR-seq mESC enhancer starr_14330 Neighboring gene coiled-coil domain containing 62 Neighboring gene STARR-positive B cell enhancer mm9_chr5:124397405-124397706 Neighboring gene STARR-positive B cell enhancer ABC_E6380 Neighboring gene STARR-positive B cell enhancer ABC_E1689 Neighboring gene predicted gene, 46922 Neighboring gene huntingtin interacting protein 1 related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock. Castelo-Szekely V, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30982898, Free PMC Article
    2. De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation. Haas MA, et al. Cell Rep, 2016 Jun 7. PMID 27239039, Free PMC Article
    3. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Korobova F, et al. Science, 2013 Jan 25. PMID 23349293, Free PMC Article
    4. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    5. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clock is a DENR target in mouse circadian timekeeping
      Title: Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock.
    2. Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1.
      Title: De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    density-regulated protein
    Names
    DRP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417688.1 → NP_001404617.1  density-regulated protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122753
      UniProtKB/Swiss-Prot
      Q3UXY1, Q9CQJ6
      Related
      ENSMUSP00000126174.2, ENSMUST00000166233.2

    2. NM_001417689.1 → NP_001404618.1  density-regulated protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122753

    3. NM_001417690.1 → NP_001404619.1  density-regulated protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122753

    4. NM_001417691.1 → NP_001404620.1  density-regulated protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122753

    5. NM_001417692.1 → NP_001404621.1  density-regulated protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AC122753

    6. NM_026603.5 → NP_080879.1  density-regulated protein isoform a

      See identical proteins and their annotated locations for NP_080879.1

      Status: VALIDATED

      Source sequence(s)
      AC122753
      Consensus CDS
      CCDS39275.1
      UniProtKB/Swiss-Prot
      Q3UXY1, Q9CQJ6
      UniProtKB/TrEMBL
      E9Q0G1
      Related
      ENSMUSP00000023869.9, ENSMUST00000023869.15
      Conserved Domains (1) summary
      TIGR01159
      Location:28 → 193
      DRP1; density-regulated protein DRP1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124045309..124066705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQJ6.1 GenPept UniProtKB/Swiss-Prot:Q9CQJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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