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    Pvr poliovirus receptor [ Mus musculus (house mouse) ]

    Gene ID: 52118, updated on 19-Feb-2024

    Summary

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    Official Symbol
    Pvrprovided by MGI
    Official Full Name
    poliovirus receptorprovided by MGI
    Primary source
    MGI:MGI:107741
    See related
    Ensembl:ENSMUSG00000040511 AllianceGenome:MGI:107741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PVS; mE4; HVED; Taa1; CD155; Tage4; necl-5; D7Ertd458e; 3830421F03Rik
    Summary
    Enables dynein light chain binding activity. Acts upstream of or within cell migration and cell-cell adhesion. Located in cell surface and plasma membrane. Orthologous to human PVR (PVR cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.4), placenta adult (RPKM 14.0) and 28 other tissues See more
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    Genomic context

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    Location:
    7 A3; 7 9.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19637503..19655068, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19903578..19921143, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 16 Neighboring gene predicted gene, 19345 Neighboring gene STARR-positive B cell enhancer ABC_E11343 Neighboring gene STARR-seq mESC enhancer starr_18229 Neighboring gene CEA cell adhesion molecule 19 Neighboring gene ribosomal protein L14 pseudogene Neighboring gene predicted gene 16251 Neighboring gene STARR-seq mESC enhancer starr_18231 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20517919-20518126 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20518638-20518747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20520941-20521094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20525341-20525450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20525675-20525828 Neighboring gene immunoglobulin superfamily, member 23 Neighboring gene ribosomal protein L7A, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity. Saha S, et al. Sci Rep, 2023 Mar 21. PMID 36944702, Free PMC Article
    2. Necl-5/PVR enhances PDGF-induced attraction of growing microtubules to the plasma membrane of the leading edge of moving NIH3T3 cells. Minami A, et al. Genes Cells, 2010 Nov. PMID 20964795
    3. CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus. Qiu Q, et al. J Immunol, 2010 Feb 15. PMID 20048123
    4. Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate. Abe A, et al. J Pathol, 2009 Jan. PMID 18973187
    5. Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lungs. Morimoto K, et al. Oncogene, 2008 Jan 10. PMID 17637752

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD155 is essential for skeletal muscle regeneration by regulating satellite cell proliferation and differentiation.
      Title: CD155 is essential for skeletal muscle regeneration by regulating satellite cell proliferation and differentiation.
    2. The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity.
      Title: The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity.
    3. T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.
      Title: T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.
    4. Results indicate that TIGIT enhanced on tolerant T cells may function as a ligand of its paired receptor CD155 to transduce signaling into its expressing naive T cells to accelerate new TIGIT expressions as well as IL-2 suppression via B lymphocyte-induced maturation protein 1 enhancement.
      Title: CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity.
    5. The hybrid complex structure of CD226-ecto binding to the first domain of CD155 (hCD155-D1) reveals a conserved binding interface with the first domain of CD226 (D1), whereas the second domain of CD226 (D2) both provides structural supports for the unique architecture of CD226 and forms direct interactions with CD155.
      Title: Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
    6. Data show that CD155 protein/CD226 antigen mainly mediates the interaction between NK cells and leukemic cells in acute myeloid leukemia. To investigate the interaction between leukemic cells
      Title: NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions.
    7. absence of either CD155 or CD226 in BALB/c mice causes a profound shift in the Natural Killer T-Cells subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells.
      Title: CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation.
    8. Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors.
      Title: Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice.
    9. CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
      Title: CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
    10. Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis
      Title: CEACAM2-L on spermatids interacts with poliovirus receptor on Sertoli cells in mouse seminiferous epithelium.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein light chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in susceptibility to T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in susceptibility to natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    poliovirus receptor
    Names
    tumor-associated antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027514.2 → NP_081790.1  poliovirus receptor precursor

      See identical proteins and their annotated locations for NP_081790.1

      Status: VALIDATED

      Source sequence(s)
      BC032283, BY276828
      Consensus CDS
      CCDS20916.1
      UniProtKB/TrEMBL
      Q8BVF6, Q8K094, Q91WP1
      Related
      ENSMUSP00000039205.8, ENSMUST00000043517.8
      Conserved Domains (3) summary
      cd05718
      Location:44 → 142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145 → 240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:35 → 141
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19637503..19655068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009310.1: Suppressed sequence

      Description
      NM_009310.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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