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    ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Homo sapiens (human) ]

    Gene ID: 338596, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ST8SIA6provided by HGNC
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by HGNC
    Primary source
    HGNC:HGNC:23317
    See related
    Ensembl:ENSG00000148488 MIM:610139; AllianceGenome:HGNC:23317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIA8F; SIAT8F; SIAT8-F; ST8SiaVI; ST8SIA-VI
    Summary
    This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in lung (RPKM 3.3), heart (RPKM 1.0) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10p12.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17315421..17454595, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17333849..17473031, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17357420..17496594, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2181 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:17268719-17268933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2182 Neighboring gene Sharpr-MPRA regulatory region 14556 Neighboring gene VIM antisense RNA 1 Neighboring gene vimentin Neighboring gene MPRA-validated peak886 silencer Neighboring gene ST8SIA6 antisense RNA 1 Neighboring gene uncharacterized LOC105376436 Neighboring gene uncharacterized LOC105376437 Neighboring gene Sharpr-MPRA regulatory region 15274 Neighboring gene Sharpr-MPRA regulatory region 12998 Neighboring gene PRP38 domain containing A pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The α2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer. Hatanaka R, et al. Biochem Biophys Res Commun, 2022 Jun 11. PMID 35390672
    2. ST8SIA6-AS1 promotes the development of hepatocellular carcinoma cells through miR-338-3p/NONO Axis. Kuai J, et al. Dig Liver Dis, 2021 Sep. PMID 33722502
    3. The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in Hepatocellular Carcinoma. Qin SJ, et al. Clin Lab, 2020 Dec 1. PMID 33337846
    4. Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer. Chen Z, et al. J Gene Med, 2021 Feb. PMID 33037712
    5. Upregulation of Human ST8Sia VI (α2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells. Yoon HK, et al. Int J Mol Sci, 2016 Aug 2. PMID 27490539, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ST8SIA6-AS1 contributes to hepatocellular carcinoma progression by targeting miR-142-3p/HMGA1 axis.
      Title: ST8SIA6-AS1 contributes to hepatocellular carcinoma progression by targeting miR-142-3p/HMGA1 axis.
    2. The alpha2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer.
      Title: The α2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer.
    3. ST8SIA6-AS1 promotes the development of hepatocellular carcinoma cells through miR-338-3p/NONO Axis.
      Title: ST8SIA6-AS1 promotes the development of hepatocellular carcinoma cells through miR-338-3p/NONO Axis.
    4. Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer.
      Title: Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer.
    5. The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in Hepatocellular Carcinoma.
      Title: The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in Hepatocellular Carcinoma.
    6. Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
      Title: Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
    7. ST8SIA6 gene is involved in the development of multidrug resistance via PI3K/Akt pathway in chronic myeloid leukemia.
      Title: α-2,8-Sialyltransferase Is Involved in the Development of Multidrug Resistance via PI3K/Akt Pathway in Human Chronic Myeloid Leukemia.
    8. NK cells consistently expressed mRNA encoding ST8Sia VI, which creates alpha2,8-linked disialic acids on O-linked glycans of glycoproteins and NK cells variably expressed high levels of ST8Sia V mRNA required for GT3 expression.
      Title: Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blastocyst hatching IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in glycolipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2,8-sialyltransferase 8F
    Names
    ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6
    sialyltransferase 8F (alpha-2, 8-sialyltransferase)
    sialyltransferase St8Sia VI
    NP_001004470.1
    NP_001332890.1
    XP_016871663.1
    XP_024303745.1
    XP_024303746.1
    XP_047281110.1
    XP_054221689.1
    XP_054221690.1
    XP_054221691.1
    XP_054221692.1
    XP_054221693.1
    XP_054221694.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051597.1 RefSeqGene

      Range
      6372..145546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004470.3 → NP_001004470.1  alpha-2,8-sialyltransferase 8F isoform 1

      See identical proteins and their annotated locations for NP_001004470.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL158164, AL160289, BC137103
      Consensus CDS
      CCDS31158.1
      UniProtKB/Swiss-Prot
      B0YJ97, B9EH72, P61647, Q5VZH4
      UniProtKB/TrEMBL
      Q1HAZ0
      Related
      ENSP00000366827.4, ENST00000377602.5
      Conserved Domains (1) summary
      pfam00777
      Location:138 → 391
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001345961.2 → NP_001332890.1  alpha-2,8-sialyltransferase 8F isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL158164, AL160289
      Conserved Domains (1) summary
      pfam00777
      Location:15 → 240
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_144322.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL158164, AL160289, BC144472

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      17315421..17454595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016174.2 → XP_016871663.1  alpha-2,8-sialyltransferase 8F isoform X1

      UniProtKB/TrEMBL
      Q1HAZ0

    2. XM_024447977.2 → XP_024303745.1  alpha-2,8-sialyltransferase 8F isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:15 → 240
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_024447978.2 → XP_024303746.1  alpha-2,8-sialyltransferase 8F isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:15 → 240
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_047425154.1 → XP_047281110.1  alpha-2,8-sialyltransferase 8F isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      17333849..17473031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365714.1 → XP_054221689.1  alpha-2,8-sialyltransferase 8F isoform X1

    2. XM_054365716.1 → XP_054221691.1  alpha-2,8-sialyltransferase 8F isoform X2

    3. XM_054365718.1 → XP_054221693.1  alpha-2,8-sialyltransferase 8F isoform X2

    4. XM_054365715.1 → XP_054221690.1  alpha-2,8-sialyltransferase 8F isoform X2

    5. XM_054365719.1 → XP_054221694.1  alpha-2,8-sialyltransferase 8F isoform X2

    6. XM_054365717.1 → XP_054221692.1  alpha-2,8-sialyltransferase 8F isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61647.1 GenPept UniProtKB/Swiss-Prot:P61647

    Gene LinkOut

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