PGLYRP2 peptidoglycan recognition protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGLYRP2provided by HGNC
Official Full Name: peptidoglycan recognition protein 2provided by HGNC
Primary source: HGNC:HGNC:30013
See related: Ensembl:ENSG00000161031 MIM:608199; AllianceGenome:HGNC:30013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
Expression: Restricted expression toward liver (RPKM 52.9) See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19p13.12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (15468645..15479501, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (15593641..15604523, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (15579456..15590312, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population.
Title: Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population.
PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
Title: PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis.
Title: Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis.
Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
Title: Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
Title: Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
The expression of IL-36gamma by oral epithelial cells in response to P. gingivalis might enable the subsequent autocrine stimulation of PGLYRP2 expression. Our data identify how IL-36gamma may promote oral mucosal homeostasis by regulating PGLYRP2 expression.
Title: Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ.
a significant induction of three PGLYRPs 2-4 in primary human corneal epithelial cells (HCECs) exposed to live or heat-killed Candida albicans, is reported.
Title: A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.
This study demonistrated that PGLYRP2 single-nucleotide polymorphisms is risk of Parkinson's disease.
Title: Peptidoglycan recognition protein genes and risk of Parkinson's disease.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Various types of human blood cells were tested for expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which belong to the family of proteins possessing the lysozyme-like peptidoglycan recognition protein (PGRP) domain
Title: [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells].

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylmuramoyl-L-alanine amidase activity	TAS Traceable Author Statement more info	PubMed
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidoglycan immune receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan immune receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological process involved in interaction with host	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of natural killer cell differentiation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in peptide amidation	NAS Non-traceable Author Statement more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: N-acetylmuramoyl-L-alanine amidase

Names: peptidoglycan recognition protein L; peptidoglycan recognition protein long

NP_001350475.1

EC 3.5.1.28

NP_443122.3

EC 3.5.1.28

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363546.1 → NP_001350475.1 N-acetylmuramoyl-L-alanine amidase isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK055882, AY358156, BC144238

Consensus CDS

CCDS86718.1

Related

ENSP00000292609.3, ENST00000292609.8

Conserved Domains (1) summary

smart00701
Location:380 → 525

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_052890.4 → NP_443122.3 N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

See identical proteins and their annotated locations for NP_443122.3

Status: VALIDATED

Source sequence(s)

AF384856, DB041324

Consensus CDS

CCDS12330.2

UniProtKB/Swiss-Prot

A8K050, A8K8C7, B2RMZ2, B7ZM33, Q68CK1, Q96N74, Q96PD5, Q9UC60

Related

ENSP00000345968.4, ENST00000340880.5

Conserved Domains (1) summary

smart00701
Location:380 → 525

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme