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    OSTC oligosaccharyltransferase complex non-catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 58505, updated on 5-Mar-2024

    Summary

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    Official Symbol
    OSTCprovided by HGNC
    Official Full Name
    oligosaccharyltransferase complex non-catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:24448
    See related
    Ensembl:ENSG00000198856 MIM:619023; AllianceGenome:HGNC:24448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DC2
    Summary
    Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q25
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (108650599..108667820)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (111953502..111970777)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109571755..109588976)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RPL34 divergent transcript Neighboring gene uncharacterized LOC101929621 Neighboring gene VISTA enhancer hs1050 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:109541270-109542469 Neighboring gene ribosomal protein L34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:109574151-109574665 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109634746-109635604 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109635605-109636463 Neighboring gene ethanolamine-phosphate phospho-lyase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:109708719-109709219 Neighboring gene regulator of chromosome condensation 2 pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation. Bryant EM, et al. Am J Med Genet A, 2020 Jun. PMID 32267060
    2. Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo. Chen CM, et al. Kaohsiung J Med Sci, 2014 May. PMID 24751383
    3. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon. Shrimal S, et al. J Cell Biol, 2017 Nov 6. PMID 28860277, Free PMC Article
    4. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Shibatani T, et al. Biochemistry, 2005 Apr 26. PMID 15835887
    5. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation.
      Title: Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation.
    2. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase STT3A and the endoplasmic reticulum translocon.
      Title: DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.
    3. These results suggest that the upregulation of OSTC/DC2, a novel component of the oligosaccharyltransferase complex, is part of the mammalian heat shock response.
      Title: Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oligosaccharyltransferase complex subunit OSTC
    Names
    hydrophobic protein HSF-28
    oligosaccharyltransferase complex subunit (non-catalytic)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267817.2 → NP_001254746.1  oligosaccharyltransferase complex subunit OSTC isoform 2

      See identical proteins and their annotated locations for NP_001254746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC107071, AF343342, BM994257, CB110420
      Consensus CDS
      CCDS75177.1
      UniProtKB/TrEMBL
      A0A087WUD3
      Related
      ENSP00000478564.1, ENST00000613215.4

    2. NM_001267818.2 → NP_001254747.1  oligosaccharyltransferase complex subunit OSTC isoform 3

      See identical proteins and their annotated locations for NP_001254747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC107071, AF343342, BM994257, CN430159
      Consensus CDS
      CCDS58921.1
      UniProtKB/Swiss-Prot
      Q9NRP0
      Related
      ENSP00000426167.2, ENST00000512478.2
      Conserved Domains (1) summary
      pfam04756
      Location:34 → 133
      OST3_OST6; OST3 / OST6 family

    3. NM_021227.4 → NP_067050.1  oligosaccharyltransferase complex subunit OSTC isoform 1

      See identical proteins and their annotated locations for NP_067050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC054857, BM994257
      Consensus CDS
      CCDS3681.1
      UniProtKB/Swiss-Prot
      A8MYS2, B2R5H1, D6RH22, Q9NRP0, Q9P075, Q9P1R4
      Related
      ENSP00000354676.4, ENST00000361564.9
      Conserved Domains (1) summary
      pfam04756
      Location:17 → 146
      OST3_OST6; OST3 / OST6 family, transporter family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      108650599..108667820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      111953502..111970777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRP0.1 GenPept UniProtKB/Swiss-Prot:Q9NRP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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