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    RPL41 ribosomal protein L41 [ Homo sapiens (human) ]

    Gene ID: 6171, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RPL41provided by HGNC
    Official Full Name
    ribosomal protein L41provided by HGNC
    Primary source
    HGNC:HGNC:10354
    See related
    Ensembl:ENSG00000229117 MIM:613315; AllianceGenome:HGNC:10354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L41; eL41
    Summary
    Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in cytoplasmic translation. Located in endoplasmic reticulum. Part of cytosolic large ribosomal subunit and polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 1672.2), colon (RPKM 1110.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56116633..56117967)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56084231..56085565)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56510417..56511751)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6470 Neighboring gene proliferation-associated 2G4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56514939-56515936 Neighboring gene zinc finger CCCH-type containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6472 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56521723-56522384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6475 Neighboring gene extended synaptotagmin 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:56536437-56537636 Neighboring gene uncharacterized LOC124902943

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity. Wang S, et al. Neoplasia, 2010 Mar. PMID 20234822, Free PMC Article
    2. Genomic structure of the human ribosomal protein L41 gene. Go H, et al. Biochem Mol Biol Int, 1998 Dec. PMID 9891856
    3. Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41. Klaudiny J, et al. Biochem Biophys Res Commun, 1992 Sep 16. PMID 1326959
    4. RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation. Geng W, et al. J Cell Physiol, 2021 Mar. PMID 32783256
    5. Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress. Wang A, et al. J Pathol, 2011 Oct. PMID 21706477

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation.
      Title: RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation.
    2. Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples.
      Title: Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma.
    3. we show that RPL41 induces ATF4 phosphorylation and rapid degradation in the proteasome
      Title: Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress.
    4. RPL41 down-regulation is associated with breast neoplasms.
      Title: RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS32
    Names
    60S ribosomal protein L41
    HG12 protein
    homologue of yeast ribosomal protein YL41
    large ribosomal subunit protein eL41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035267.2 → NP_001030344.1  small ribosomal subunit protein eS32

      See identical proteins and their annotated locations for NP_001030344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is the longer transcript, containing a unique segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC034102, BC064907, BC082759, BF673574
      Consensus CDS
      CCDS44919.1
      UniProtKB/Swiss-Prot
      A6NG21, P28751, P62945
      UniProtKB/TrEMBL
      A0A024RB15
      Related
      ENSP00000449026.1, ENST00000546591.6
      Conserved Domains (1) summary
      pfam05162
      Location:1 → 24
      Ribosomal_L41; Ribosomal protein L41

    2. NM_021104.2 → NP_066927.1  small ribosomal subunit protein eS32

      See identical proteins and their annotated locations for NP_066927.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC034102, Z12962
      Consensus CDS
      CCDS44919.1
      UniProtKB/Swiss-Prot
      A6NG21, P28751, P62945
      UniProtKB/TrEMBL
      A0A024RB15
      Related
      ENSP00000420821.3, ENST00000501597.3
      Conserved Domains (1) summary
      pfam05162
      Location:1 → 24
      Ribosomal_L41; Ribosomal protein L41

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56116633..56117967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56084231..56085565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62945.1 GenPept UniProtKB/Swiss-Prot:P62945

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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