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    Ldha lactate dehydrogenase A [ Mus musculus (house mouse) ]

    Gene ID: 16828, updated on 21-May-2024

    Summary

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    Official Symbol
    Ldhaprovided by MGI
    Official Full Name
    lactate dehydrogenase Aprovided by MGI
    Primary source
    MGI:MGI:96759
    See related
    Ensembl:ENSMUSG00000063229 AllianceGenome:MGI:96759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ldh1; Ldhm; l7R2
    Summary
    The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in liver E18 (RPKM 539.4), mammary gland adult (RPKM 508.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ldha in Genome Data Viewer
    Location:
    7 B3; 7 30.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46491698..46505051)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46842274..46855627)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene general transcription factor II H, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_18872 Neighboring gene Rap1A-retro1 Neighboring gene STARR-seq mESC enhancer starr_18874 Neighboring gene predicted gene 5331 Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer. Liu J, et al. Nat Metab, 2022 Dec. PMID 36536137, Free PMC Article
    2. LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization. Chen Y, et al. Redox Biol, 2022 Oct. PMID 36057161, Free PMC Article
    3. Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development. Serra M, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35714859, Free PMC Article
    4. Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis. Chen Q, et al. Blood, 2022 May 12. PMID 35176139
    5. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. Varma G, et al. NMR Biomed, 2021 Aug. PMID 34086382, Free PMC Article

    See all (177) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1alpha transcriptional complex.
      Title: Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex.
    2. Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
      Title: Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
    3. STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells.
      Title: STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells.
    4. Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
      Title: Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
    5. LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization.
      Title: LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization.
    6. Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
      Title: Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
    7. Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
      Title: Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
    8. Lactate dehydrogenase regulates basal glucose uptake in adipocytes.
      Title: Lactate dehydrogenase regulates basal glucose uptake in adipocytes.
    9. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function.
      Title: Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function.
    10. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR.
      Title: Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-lactate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lactate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucose catabolic process to lactate via pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lactate biosynthetic process from pyruvate IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyruvate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxidoreductase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-lactate dehydrogenase A chain
    Names
    LDH muscle subunit
    LDH-M
    M-LDH
    lactate dehydrogenase 1, A chain
    lactate dehydrogenase A4
    NP_001129541.2
    NP_034829.1
    XP_030098036.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136069.2 → NP_001129541.2  L-lactate dehydrogenase A chain isoform 2

      See identical proteins and their annotated locations for NP_001129541.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon that results in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AK150156, BC094428, BY195537
      Consensus CDS
      CCDS52255.1
      UniProtKB/TrEMBL
      A0A1B0GSX0, Q3TCI7, Q3THB4, Q3TI99
      Related
      ENSMUSP00000148107.2, ENSMUST00000209984.2
      Conserved Domains (2) summary
      cd05293
      Location:48 → 358
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:54 → 353
      L-LDH-NAD; L-lactate dehydrogenase

    2. NM_010699.2 → NP_034829.1  L-lactate dehydrogenase A chain isoform 1

      See identical proteins and their annotated locations for NP_034829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AC090123, BC094428, BY227595
      Consensus CDS
      CCDS21289.1
      UniProtKB/Swiss-Prot
      P06151
      UniProtKB/TrEMBL
      G5E8N5, Q3TCI7, Q3THB4, Q3TI99, Q564E2
      Related
      ENSMUSP00000036386.10, ENSMUST00000048209.16
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RNA

    1. NR_102727.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK171373, AU079257, BC094428
      Related
      ENSMUST00000209548.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46491698..46505051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242176.1 → XP_030098036.1  L-lactate dehydrogenase A chain isoform X1

      UniProtKB/Swiss-Prot
      P06151
      UniProtKB/TrEMBL
      G5E8N5, Q3TCI7, Q3THB4, Q3TI99, Q564E2
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06151.3 GenPept UniProtKB/Swiss-Prot:P06151

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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