H60c histocompatibility 60c [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H60cprovided by MGI
Official Full Name: histocompatibility 60cprovided by MGI
Primary source: MGI:MGI:3774845
See related: Ensembl:ENSMUSG00000091618 AllianceGenome:MGI:3774845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm9491; 4632413I24Rik
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Is anchored component of plasma membrane. Orthologous to human RAET1E (retinoic acid early transcript 1E). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 2.8), limb E14.5 (RPKM 0.8) and 5 other tissues See more
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Genomic context

Location:: 10 A1; 10 2.08 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (3206202..3218091, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (3256202..3268091, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a more general role for H60c in the maintenance of epithelial integrity.
Title: Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair.
Identified two novel mouse chromosome 10-encoded NKG2D ligands, H60b and H60c, structurally resembling H60.
Title: Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables natural killer cell lectin-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell mediated cytotoxicity	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histocompatibility antigen 60c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204916.2 → NP_001191845.1 histocompatibility antigen 60c precursor

See identical proteins and their annotated locations for NP_001191845.1

Status: VALIDATED

Source sequence(s)

AB284506, AC157021, AK014573

Consensus CDS

CCDS56668.1

UniProtKB/Swiss-Prot

B1B213

UniProtKB/TrEMBL

A0A1L1SRI2

Related

ENSMUSP00000126536.3, ENSMUST00000170893.3

Conserved Domains (1) summary

cl08246
Location:16 → 133

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

3206202..3218091 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245226.1 → XP_030101086.1 histocompatibility antigen 60c isoform X3

Conserved Domains (1) summary

cl08246
Location:99 → 216

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
XM_030245225.1 → XP_030101085.1 histocompatibility antigen 60c isoform X2

UniProtKB/TrEMBL

A0A1L1SRI2

Related

ENSMUSP00000149470.2, ENSMUST00000216211.2

Conserved Domains (1) summary

cl08246
Location:98 → 215

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
XM_006512485.4 → XP_006512548.1 histocompatibility antigen 60c isoform X1

UniProtKB/TrEMBL

A0A1L1SRI2

Conserved Domains (1) summary

cl08246
Location:99 → 216

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2