DHRS2 dehydrogenase/reductase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DHRS2provided by HGNC
Official Full Name: dehydrogenase/reductase 2provided by HGNC
Primary source: HGNC:HGNC:18349
See related: Ensembl:ENSG00000100867 MIM:615194; AllianceGenome:HGNC:18349
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HEP27; SDR25C1
Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Expression: Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (23630115..23645639)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (17830743..17846267)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (24099324..24114848)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.
Title: Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.
Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.
Title: Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.
DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKalpha to disrupt choline metabolism.
Title: DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.
LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells
Title: LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells.
Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.
Title: Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.
DHRS2 is dispensable for up-regulation of romidepsin effectors.
Title: Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors.
Results show that DHRS2 is highly expressed in oxaliplatin-resistant colorectal cancer (CRC) cell line. Furthermore, DHRS2 regulates ERCC1 to promote oxaliplatin resistance through a p53dependent pathway, and mediates EMT by suppressing Ecadherin expression.
Title: Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Our report suggests that activating DHRS2 to reprogram lipid homeostasis may be a target for the development of targeted therapies against NPC.
Title: DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma.
Among these targets, dehydrogenase/reductase member 2 DHRS2 and MYO1B were directly regulated by miR1453p in esophageal squamous cell carcinoma (ESCC) cells by dual luciferase reporter assays. Aberrantly expressed DHRS2 and MYOIB were detected in ESCC clinical specimens, and their overexpression enhanced cancer cell aggressiveness.
Title: Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation.
Low DHRS2 expression promotes esophageal squamous cell carcinoma.
Title: DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47141 (e-PCR)
- UniSTS:51984

G49463 (e-PCR)
- UniSTS:109202

RH71221 (e-PCR)
- UniSTS:57274

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in C21-steroid hormone metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in myeloid dendritic cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in response to toxic substance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 2, mitochondrial

Names: dehydrogenase/reductase (SDR family) member 2; dehydrogenase/reductase member 2; dicarbonyl reductase HEP27; protein D; short chain dehydrogenase/reductase family 25C member 1; short-chain alcohol dehydrogenase family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318835.1 → NP_001305764.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 1. This results in a protein that is shorter at the C-terminus, compared to isoform 1. The promoter used by this transcript is a hepatocyte specific promoter.

Source sequence(s)

AK309975, AL135999

UniProtKB/TrEMBL

Q59F08

Related

ENST00000553896.5

Conserved Domains (1) summary

cl21454
Location:27 → 140

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_005794.4 → NP_005785.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_005785.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). The promoter used by this transcript is a hepatocyte-specific promoter.

Source sequence(s)

AK222857, U31875

Consensus CDS

CCDS9604.1

UniProtKB/Swiss-Prot

D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

UniProtKB/TrEMBL

C9JZP6

Related

ENSP00000250383.7, ENST00000250383.11

Conserved Domains (1) summary

cl21454
Location:27 → 275

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_182908.5 → NP_878912.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_878912.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR. (PMID: 11944995) This promoter is specifically active in human monocyte-derived dendritic cells.

Source sequence(s)

AL135999, BC002786

Consensus CDS

CCDS41927.1

UniProtKB/Swiss-Prot

Q13268

Related

ENSP00000344674.7, ENST00000344777.11

Conserved Domains (1) summary

cl25409
Location:27 → 226

SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

23630115..23645639

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005267249.1 → XP_005267306.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_005267306.1

UniProtKB/Swiss-Prot

D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

UniProtKB/TrEMBL

C9JZP6

Related

ENSP00000401213.2, ENST00000432832.6

Conserved Domains (1) summary

cl21454
Location:27 → 275

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011536339.3 → XP_011534641.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_011534641.1

UniProtKB/TrEMBL

H0YJP4

Related

ENSP00000451895.1, ENST00000557535.5

Conserved Domains (1) summary

cl21454
Location:1 → 199

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006720001.4 → XP_006720064.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006720064.1

UniProtKB/Swiss-Prot

D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

UniProtKB/TrEMBL

C9JZP6

Conserved Domains (1) summary

cl21454
Location:27 → 275

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011536338.2 → XP_011534640.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_011534640.1

UniProtKB/TrEMBL

H0YJP4

Conserved Domains (1) summary

cl21454
Location:1 → 199

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_047430874.1 → XP_047286830.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

RNA

XR_007063975.1 RNA Sequence
XR_007063976.1 RNA Sequence
XR_007063974.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

17830743..17846267

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054375248.1 → XP_054231223.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
XM_054375252.1 → XP_054231227.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2
XM_054375249.1 → XP_054231224.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
XM_054375251.1 → XP_054231226.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2
XM_054375250.1 → XP_054231225.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2