FCGR3B Fc gamma receptor IIIb [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCGR3Bprovided by HGNC
Official Full Name: Fc gamma receptor IIIbprovided by HGNC
Primary source: HGNC:HGNC:3620
See related: Ensembl:ENSG00000162747 MIM:610665; AllianceGenome:HGNC:3620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD16; FCG3; CD16A; CD16b; FCGR3; CD16-I; FCGR3A; FCR-10; FCRIII; FCRIIIb
Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Expression: Biased expression in spleen (RPKM 53.3), appendix (RPKM 50.9) and 7 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q23.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (161623196..161631963, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (160967541..160976307, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (161592986..161601753, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.
Title: Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.
Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
Title: Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
Significant differences in FcgammaRIIa, FcgammaRIIIa and FcgammaRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
Title: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
Low-affinity immunoglobulin gamma Fc region receptor III-B (FcgammaRIIIB, CD16B) deficiency in patients with blood and immune system disorders.
Title: Low-affinity immunoglobulin gamma Fc region receptor III-B (FcγRIIIB, CD16B) deficiency in patients with blood and immune system disorders.
The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.
Title: The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.
Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
Title: Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.
Title: FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.
Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
Title: Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
Aberrant FcgammaRIIb and FcgammaRIII expression on monocytes from patients with Behcet's disease.
Title: Aberrant FcγRIIb and FcγRIII expression on monocytes from patients with Behçet's disease.
FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.
Title: FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.

Submit: New GeneRIF Correction See all GeneRIFs (132)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of CCR2, CD16, and TLR4 in monocyte-derived macrophages	PubMed
	tat	HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC20248P1 (e-PCR)
- UniSTS:271891

NoName (e-PCR)
- UniSTS:480827

RH11453 (e-PCR)
- UniSTS:65438

SHGC-35267 (e-PCR)
- UniSTS:28353

PMC26659P2 (e-PCR)
- UniSTS:272344

GDB:190042 (e-PCR)
- UniSTS:155612

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GPI anchor binding	IDA Inferred from Direct Assay more info	PubMed
enables IgG binding	IEA Inferred from Electronic Annotation more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor III-B

Names: Fc fragment of IgG receptor IIIb; Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc gamma receptor III-B; Fc-gamma receptor IIIb (CD 16); FcgammaRIIIb; fc-gamma RIII-beta; fc-gamma RIIIb; igG Fc receptor III-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032926.2 RefSeqGene

Range

5788..13768

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1238

mRNA and Protein(s)

NM_000570.5 → NP_000561.3 low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

See identical proteins and their annotated locations for NP_000561.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (2).

Source sequence(s)

AL451067

Consensus CDS

CCDS41433.1

UniProtKB/Swiss-Prot

O75015

UniProtKB/TrEMBL

A0A3B3ISU3, Q9UPY7

Related

ENSP00000356941.2, ENST00000367964.6

Conserved Domains (2) summary

cd05752
Location:26 → 104

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:108 → 190

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_001244753.2 → NP_001231682.2 low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (2). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AJ581669, AL451067, M24854, X16863

Consensus CDS

CCDS41433.1

UniProtKB/Swiss-Prot

O75015

UniProtKB/TrEMBL

A0A3B3ISU3, Q9UPY7

Related

ENSP00000497461.1, ENST00000650385.1

Conserved Domains (2) summary

cd05752
Location:26 → 104

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:108 → 190

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_001271035.2 → NP_001257964.2 low affinity immunoglobulin gamma Fc region receptor III-B isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is one aa shorter compared to isoform 2.

Source sequence(s)

AJ581669, AK316565, AL451067, DA673839

Consensus CDS

CCDS91090.1

UniProtKB/TrEMBL

H0Y4U3, Q9UPY7

Related

ENSP00000394204.3, ENST00000421702.4

Conserved Domains (2) summary

cd05752
Location:25 → 103

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:107 → 189

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_001271036.2 → NP_001257965.1 low affinity immunoglobulin gamma Fc region receptor III-B isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL451067

UniProtKB/TrEMBL

Q9UPY7

Conserved Domains (2) summary

cd05752
Location:9 → 87

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cd05753
Location:91 → 173

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001271037.2 → NP_001257966.1 low affinity immunoglobulin gamma Fc region receptor III-B isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AL451067

UniProtKB/Swiss-Prot

O75015

UniProtKB/TrEMBL

A0A087WU90

Conserved Domains (1) summary

cd05752
Location:9 → 87

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains