Slfn8 schlafen 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slfn8provided by MGI
Official Full Name: schlafen 8provided by MGI
Primary source: MGI:MGI:2672859
See related: Ensembl:ENSMUSG00000035208 AllianceGenome:MGI:2672859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mSLFN8
Summary: Enables endoribonuclease activity. Involved in rRNA catabolic process and tRNA catabolic process. Predicted to be located in cytosol; nucleoplasm; and site of DNA damage. Orthologous to human SLFN11 (schlafen family member 11) and SLFN13 (schlafen family member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 1.4), thymus adult (RPKM 1.2) and 24 other tissues See more
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Genomic context

Location:: 11 C; 11 50.3 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (82892984..82911636, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83002125..83020810, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
Title: Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
We demonstrated that Slfn8-/- mice were resistant to the development of EAE.
Title: Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.
several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
Title: Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.
functional participation of slfn8 in the regulatory networks governing T cell development and growth appears to be cell type specific
Title: Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

D11Pas14 (e-PCR), detects polymorphism
- UniSTS:209576

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in rRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tRNA decay	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA decay	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: schlafen family member 8

Names: Schlafen family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167743.1 → NP_001161215.1 schlafen family member 8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks one exon in the 5' UTR and one exon in the CDS, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.

Source sequence(s)

AL603745, BC152549

Consensus CDS

CCDS48869.1

UniProtKB/TrEMBL

A0A1G5SJK5, E9Q0R4

Related

ENSMUSP00000103787.3, ENSMUST00000108152.9

Conserved Domains (2) summary

PHA02782
Location:45 → 346

PHA02782; hypothetical protein; Provisional

pfam04326
Location:205 → 316

AlbA_2; Putative DNA-binding domain
NM_181545.4 → NP_853523.2 schlafen family member 8 isoform 1

See identical proteins and their annotated locations for NP_853523.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL603745, AY261798

Consensus CDS

CCDS25155.1

UniProtKB/Swiss-Prot

A0A0A0MQG0, B1ARD8, F6RTS1, Q3UBN9, Q7TMF1

UniProtKB/TrEMBL

A0A1G5SJB6, Q7TMF0

Related

ENSMUSP00000040060.9, ENSMUST00000038141.15

Conserved Domains (4) summary

PHA02782
Location:45 → 346

PHA02782; hypothetical protein; Provisional

pfam13401
Location:595 → 678

AAA_22; AAA domain

pfam09848
Location:595 → 765

DUF2075; Uncharacterized conserved protein (DUF2075)

pfam13538
Location:852 → 896

UvrD_C_2; UvrD-like helicase C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

82892984..82911636 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156744.1 → XP_036012637.1 schlafen family member 8 isoform X1

UniProtKB/Swiss-Prot

A0A0A0MQG0, B1ARD8, F6RTS1, Q3UBN9, Q7TMF1

UniProtKB/TrEMBL

A0A1G5SJB6, Q7TMF0

Related

ENSMUSP00000090513.5, ENSMUST00000092838.11

Conserved Domains (4) summary

PHA02782
Location:45 → 346

PHA02782; hypothetical protein; Provisional

pfam13401
Location:595 → 678

AAA_22; AAA domain

pfam09848
Location:595 → 765

DUF2075; Uncharacterized conserved protein (DUF2075)

pfam13538
Location:852 → 896

UvrD_C_2; UvrD-like helicase C-terminal domain