Ifit1 interferon-induced protein with tetratricopeptide repeats 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifit1provided by MGI
Official Full Name: interferon-induced protein with tetratricopeptide repeats 1provided by MGI
Primary source: MGI:MGI:99450
See related: Ensembl:ENSMUSG00000034459 AllianceGenome:MGI:99450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P56; ISG56; Ifi56; GARG-16; IFI-56K
Summary: Predicted to enable RNA binding activity. Involved in response to virus. Acts upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; eye; and genitourinary system. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 7.6), liver E18 (RPKM 5.2) and 23 other tissues See more
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Genomic context

Location:: 19 C1; 19 29.78 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (34618289..34627409)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (34640889..34650009)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
Title: Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
Overexpression of IFIT1 protects against LPS-induced acute lung injury via regulating CCL5-p65NF-kappaB signaling.
Title: Overexpression of IFIT1 protects against LPS-induced acute lung injury via regulating CCL5-p65NF-κB signaling.
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling.
Title: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling.
PolyI:C stimulated BMM of Tlr3(-/-) mice showed a reduction of Ifit1 (p=0.003) and Mx1 (p<0.0001) mRNA compared to control. We here demonstrate that TLR3 can play a protective role in VGD development, possibly regulated via type-I IFNs and a reduced inflammatory response.
Title: The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease.
ISG20 acts as an indirect regulator of RNA virus replication in the cytoplasm through the upregulation of many other ISGs.
Title: The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.
IFIT1 expression is associated with podocytes damage, and capable of suppressing some proteins essential to glomerular filtration.
Title: The association between expression of IFIT1 in podocytes of MRL/lpr mice and the renal pathological changes it causes: An animal study.
Human IFIT1 and mouse IFIT1 have divergent antiviral specificities: only IFIT1 proteins inhibit a virus encoding a cap 2'O-methyltransferase.
Title: Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals.
the mechanism for the observed differential induction of the mouse Ifit1, Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly expressed in B cells, played an essential role in this regulation.
Title: Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.
Data suggest that, with up-regulation of IFIT1, alphaviruses (Venezuelan equine encephalitis virus; Chikungunya virus) with wild-type 5' untranslated regions are inducers of type I IFN (interferon), suggesting a new mechanism of type I IFN induction.
Title: IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.
Targeted expression of Ifit1 in hepatocytes protects mice from lipopolysaccharide and D-galactosamine induced lethal hepatitis.
Title: Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ifit1 (e-PCR), detects polymorphism
- UniSTS:472857

U43084 (e-PCR)
- UniSTS:163612

Ifit1 (e-PCR), detects polymorphism
- UniSTS:506992

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to virus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 1

Names: glucocorticoid-attenuated response gene 16 protein; interferon-induced 56 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008331.4 → NP_032357.2 interferon-induced protein with tetratricopeptide repeats 1

See identical proteins and their annotated locations for NP_032357.2

Status: VALIDATED

Source sequence(s)

AC016791

Consensus CDS

CCDS29766.1

UniProtKB/Swiss-Prot

Q64282, Q99L77

UniProtKB/TrEMBL

Q3U5K8, Q3U5N2, Q3U7A2, Q3UNG3, Q8BN43

Related

ENSMUSP00000099888.4, ENSMUST00000102824.4

Conserved Domains (4) summary

TIGR02521
Location:194 → 354

type_IV_pilW; type IV pilus biogenesis/stability protein PilW

sd00006
Location:242 → 270

TPR; TPR repeat [structural motif]

pfam13424
Location:54 → 124

TPR_12; Tetratricopeptide repeat

pfam13432
Location:145 → 208

TPR_16; Tetratricopeptide repeat