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    ZFP82 ZFP82 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 284406, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZFP82provided by HGNC
    Official Full Name
    ZFP82 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:28682
    See related
    Ensembl:ENSG00000181007 AllianceGenome:HGNC:28682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF545
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.5), brain (RPKM 1.3) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36383120..36418644, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39058035..39093577, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36874022..36909546, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36818663-36819164 Neighboring gene MPRA-validated peak3460 silencer Neighboring gene ZFP14 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36912605-36913287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919277-36919778 Neighboring gene acyl-CoA thioesterase 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919779-36920278 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:36939953-36941152 Neighboring gene zinc finger protein 566 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36979559-36980446 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36980447-36981332

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and invasion of esophageal carcinoma cells through inhibiting NF-κB transcription and inducing apoptosis. Ye L, et al. Epigenomics, 2019 Jan. PMID 30211622
    2. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. Xiang S, et al. Int J Oncol, 2017 Sep. PMID 28677721, Free PMC Article
    3. Poor survival is associated with the methylated degree of zinc-finger protein 545 (ZNF545) DNA promoter in gastric cancer. Deng J, et al. Oncotarget, 2015 Feb 28. PMID 25714013, Free PMC Article
    4. Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis and is disrupted by promoter methylation in breast cancer. Xiao Y, et al. PLoS One, 2014. PMID 25360542, Free PMC Article
    5. Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer. Wang S, et al. Gut, 2013 Jun. PMID 22580414

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFP82 is a tumor suppressor and is disrupted by promoter CpG methylation during esophageal carcinogenesis.
      Title: The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and invasion of esophageal carcinoma cells through inhibiting NF-κB transcription and inducing apoptosis.
    2. ZNF545 protein promoted the apoptosis of myeloma cells.
      Title: The role of MIR-186 and ZNF545 in inhibiting the proliferation of multiple myeloma cells.
    3. the results suggested that ZNF545 functions as a tumor suppressor in colorectal cancer and is frequently inactivated by promoter methylation.
      Title: Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer.
    4. These findings indicated that the methylated CpG sites of the ZNF545 promoter could be used for the clinical prediction of the prognosis of gastric cancer
      Title: Poor survival is associated with the methylated degree of zinc-finger protein 545 (ZNF545) DNA promoter in gastric cancer.
    5. ZNF545 inhibits breast tumor cell proliferation through inducing apoptosis and is disrupted by promoter methylation in breast cancer.
      Title: Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis and is disrupted by promoter methylation in breast cancer.
    6. ZNF545 acts as a functional tumour suppressor in gastric cancer by inhibiting rRNA transcription.
      Title: Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1948, MGC45380

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 82 homolog
    Names
    zinc finger protein 545
    zinc finger protein 85

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321917.2 → NP_001308846.1  zinc finger protein 82 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092296, AL707725, BX491216
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:144 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:341 → 361
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001321918.2 → NP_001308847.1  zinc finger protein 82 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092296, BX491216
      Conserved Domains (1) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box

    3. NM_001321919.2 → NP_001308848.1  zinc finger protein 82 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC092296, BX491216
      Conserved Domains (2) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box
      pfam01352
      Location:6 → 45
      KRAB; KRAB box

    4. NM_133466.4 → NP_597723.1  zinc finger protein 82 homolog isoform 1

      See identical proteins and their annotated locations for NP_597723.1

      Status: VALIDATED

      Source sequence(s)
      AC092296, AL707725, AL834267
      Consensus CDS
      CCDS12493.1
      UniProtKB/Swiss-Prot
      Q8N141, Q8NC63, Q8TF53
      UniProtKB/TrEMBL
      D3Y299
      Related
      ENSP00000431265.1, ENST00000392161.4
      Conserved Domains (3) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box
      COG5048
      Location:143 → 526
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:340 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36383120..36418644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39058035..39093577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N141.1 GenPept UniProtKB/Swiss-Prot:Q8N141

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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