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    ANKRD22 ankyrin repeat domain 22 [ Homo sapiens (human) ]

    Gene ID: 118932, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ANKRD22provided by HGNC
    Official Full Name
    ankyrin repeat domain 22provided by HGNC
    Primary source
    HGNC:HGNC:28321
    See related
    Ensembl:ENSG00000152766 AllianceGenome:HGNC:28321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in stomach (RPKM 14.2), skin (RPKM 12.9) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q23.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88819896..88851844, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89703828..89735790, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90579653..90611601, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:90518932-90520131 Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1 Neighboring gene lipase family member M Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3726 Neighboring gene uncharacterized LOC124902551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2589 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene STAM binding protein like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ANKRD22 is an N-myristoylated hairpin-like monotopic membrane protein specifically localized to lipid droplets. Utsumi T, et al. Sci Rep, 2021 Sep 28. PMID 34584137, Free PMC Article
    2. ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells. Pan T, et al. Theranostics, 2020. PMID 31903135, Free PMC Article
    3. ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1. Yin J, et al. Sci Rep, 2017 Jun 30. PMID 28667340, Free PMC Article
    4. ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression. Liu X, et al. J Neuropathol Exp Neurol, 2023 Jun 20. PMID 37164633
    5. High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines. Wang S, et al. Int J Mol Sci, 2018 Dec 19. PMID 30572598, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANKRD22 knockdown suppresses papillary thyroid cell carcinoma growth and migration and modulates the Wnt/beta-catenin signaling pathway.
      Title: ANKRD22 knockdown suppresses papillary thyroid cell carcinoma growth and migration and modulates the Wnt/β-catenin signaling pathway.
    2. ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
      Title: ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
    3. ANKRD22 is an N-myristoylated hairpin-like monotopic membrane protein specifically localized to lipid droplets.
      Title: ANKRD22 is an N-myristoylated hairpin-like monotopic membrane protein specifically localized to lipid droplets.
    4. ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells.
      Title: ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells.
    5. ANKRD22 exhibits oncogene activity that promotes tumor progression in NSCLC through the transcriptional regulation of E2F1.
      Title: ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC22805

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144590.3 → NP_653191.2  ankyrin repeat domain-containing protein 22

      See identical proteins and their annotated locations for NP_653191.2

      Status: VALIDATED

      Source sequence(s)
      AL353113, BC021671, BM785517, DA672161, N95187
      Consensus CDS
      CCDS7390.1
      UniProtKB/Swiss-Prot
      B2R9Y7, Q5VYY1, Q8WU06
      Related
      ENSP00000360998.4, ENST00000371930.5
      Conserved Domains (3) summary
      sd00045
      Location:39 → 70
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:5 → 60
      Ank_4; Ankyrin repeats (many copies)
      cl39094
      Location:39 → 175
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      88819896..88851844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      89703828..89735790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VYY1.1 GenPept UniProtKB/Swiss-Prot:Q5VYY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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