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    Rnf10 ring finger protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 50849, updated on 12-May-2024

    Summary

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    Official Symbol
    Rnf10provided by MGI
    Official Full Name
    ring finger protein 10provided by MGI
    Primary source
    MGI:MGI:1859162
    See related
    Ensembl:ENSMUSG00000041740 AllianceGenome:MGI:1859162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RIE2; mKIAA0262
    Summary
    The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 116.7), testis adult (RPKM 98.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 56.01 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115379829..115410951, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115241770..115272921, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_14109 Neighboring gene predicted gene, 35515 Neighboring gene STARR-seq mESC enhancer starr_14111 Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_14112 Neighboring gene STARR-positive B cell enhancer ABC_E3605 Neighboring gene STARR-seq mESC enhancer starr_14114 Neighboring gene coenzyme Q5 methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E530 Neighboring gene dynein light chain LC8-type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells. Malik YS, et al. J Cell Biochem, 2013 Sep. PMID 23526782
    2. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. Seki N, et al. J Hum Genet, 2000. PMID 10697961
    3. Characterization of hampin/MSL1 as a node in the nuclear interactome. Dmitriev RI, et al. Biochem Biophys Res Commun, 2007 Apr 20. PMID 17335777, Free PMC Article
    4. Rapid and Integrative Discovery of Retina Regulatory Molecules. Albrecht NE, et al. Cell Rep, 2018 Aug 28. PMID 30157441, Free PMC Article
    5. A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies. Tiu GC, et al. Dev Cell, 2021 Jul 26. PMID 34242585, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0262

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Schwann cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynapse to nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF10
    Names
    sid 2705
    NP_001289377.1
    NP_001289378.1
    NP_001412439.1
    NP_057907.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302448.2 → NP_001289377.1  E3 ubiquitin-protein ligase RNF10 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC145070
      Consensus CDS
      CCDS80381.1
      UniProtKB/TrEMBL
      D3Z1N2, Q3U0W6
      Related
      ENSMUSP00000107726.2, ENSMUST00000112097.8
      Conserved Domains (1) summary
      pfam13923
      Location:225 → 266
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_001302449.2 → NP_001289378.1  E3 ubiquitin-protein ligase RNF10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate in-frame splice sites in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC145070
      Consensus CDS
      CCDS80380.1
      UniProtKB/TrEMBL
      H7BX06, Q3U0W6
      Related
      ENSMUSP00000041778.9, ENSMUST00000040555.15
      Conserved Domains (1) summary
      pfam13923
      Location:225 → 266
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    3. NM_001425510.1 → NP_001412439.1  E3 ubiquitin-protein ligase RNF10 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Isoforms 2 and 4 are the same length but have different sequences.
      Source sequence(s)
      AC145070

    4. NM_016698.3 → NP_057907.2  E3 ubiquitin-protein ligase RNF10 isoform 2

      See identical proteins and their annotated locations for NP_057907.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Isoforms 2 and 4 are the same length but have different sequences.
      Source sequence(s)
      AC145070
      Consensus CDS
      CCDS19584.1
      UniProtKB/Swiss-Prot
      Q3UIW5, Q6PDS8, Q6ZQE8, Q91YZ9, Q9R0P0
      UniProtKB/TrEMBL
      Q3U0W6
      Related
      ENSMUSP00000107725.3, ENSMUST00000112096.9
      Conserved Domains (1) summary
      pfam13923
      Location:225 → 266
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115379829..115410951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UIW5.2 GenPept UniProtKB/Swiss-Prot:Q3UIW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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